DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWP2 and Nedd4

DIOPT Version :9

Sequence 1:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	1026	Identity:	323/1026 - (31%)
Similarity:	451/1026 - (43%)	Gaps:	328/1026 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    43 EVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSH-LDLKVWSCHTL-RNELLGTASVNLSN 105
            ::.:|.:.::|||  |.:..:   |||..|..|....| |..:|:..:.| |::.||...:.|
  Fly   105 DINIDSVLTKTKK--KTLNPT---WNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTL-- 162

Human   106 VLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSG 170
                           :||.||.:|..:
  Fly   163 ---------------VNLPTEQEGRTI-------------------------------------- 174

Human   171 TAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTV 235
                             |.:|.|.|            ..:|.||:||.:..:: ..|:.:.....
  Fly   175 -----------------GEQSYTLR------------PRRSVGAKSRIKGTLR-IYHAFIRETRE 209

Human   236 NDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
            ..||::.....|...|..|:  |...|..|:|         .|..|.                 |
  Fly   210 QSEPSSGNSDGEWEHVEATN--AGETSAQPHP---------FPTGGH-----------------D 246

Human   301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------------------------------- 331
            |||||||:|:..|||.|||:|..:||.|:||
  Fly   247 ALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGR 311

Human   332 ------------------------------LPPGW-----------------EKRTDPRGRFYYV 349
                                          .||..                 |:..||.     |
  Fly   312 SADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPT-----V 371

Human   350 DHNT-----------------RTTTWQ---RPTAE------------------------------ 364
            ||.:                 ..|:.|   ||..|
  Fly   372 DHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQE 436

Human   365 --------YVRNYEQWQSQRNQ---------LQGAMQHFSQRFLYQ--SSSASTDH--------- 401
                    :::.::|.|.|:.|         .|...||..||...|  .|:..|||
  Fly   437 RRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDI 501

Human   402 ----------------DPL--------GPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMI 441
                            .|:        .||||.|..: ..|||.::::|.:|.|.|.|||.....
  Fly   502 SAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRAS 566

Human   442 QEP-----------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSF 495
            ..|           .||.|||.:..::|..:::|||||||.::|||....:...|..|  |.|.:
  Fly   567 PMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVP--YSRDY 629

Human   496 RWKYHQFR-FLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGG 558
            :.||..|: .:.....:|:..:|.:.|.::.|||::.|.::...| |:.:|::...||.||||||
  Fly   630 KQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGG 694

Human   559 IAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 622
            :|||||:|||.|:.||.|.||||:..:||.||||..|.: |.:||:||:||||...||:||||.:
  Fly   695 LAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLL 759

Human   623 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHEL 687
            |..|..||||.||.|...|||:||:|.|:|||::|||||:...  |||.|..|.::.|:.:.|||
  Fly   760 DAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI--LELTFCLDEDVFGQKSQHEL 822

Human   688 KEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGM 752
            |.||.:|.||.|||:|||.|:.:|||...|:||..:|||||..:.||..::.|||.||||::||:
  Fly   823 KPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGI 887

Human   753 QEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816
            |.||:.||:::|:|: .|..|...|||||:.|....||.|.|||||||||.|:|:.||.||.|||
  Fly   888 QNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSN 952

Human   817 GPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
            |||.|.|:|.|.....||:||||||||||||:.|.||::||:.|||.::||
  Fly   953 GPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		21/147 (14%)
		Atrophin-1	<164..343	CDD:331285	46/259 (18%)
		WW	302..331	CDD:306827	17/28 (61%)
		WW	332..361	CDD:306827	10/65 (15%)
		WW	407..435	CDD:306827	11/28 (39%)
		WW	447..477	CDD:238122	14/29 (48%)
		HECTc	516..868	CDD:238033	190/355 (54%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	33/188 (18%)
		WW	248..277	CDD:278809	17/28 (61%)
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	15/31 (48%)
		HECTc	650..1003	CDD:238033	188/354 (53%)
		HECTc	674..1003	CDD:214523	182/330 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11446
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740