DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WWP2 and wwp2

DIOPT Version :9

Sequence 1:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens
Sequence 2:	NP_001090841.1	Gene:	wwp2 / 100038252	XenbaseID:	XB-GENE-961516	Length:	729	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	567/768 - (73%)
Similarity:	613/768 - (79%)	Gaps:	71/768 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   113 KMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPEN 177
            |..::.|.:|||..:|   .||.:|||.||                  ..:.:.:.:.:.:..||
Frog    23 KENSVPLQINLQAAHK---ASGDDLTIALD------------------EHMEAVEDADSEMVFEN 66

Human   178 RH-------QPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTV 235
            .|       .||.:                             |.|...||:||..::......|
Frog    67 GHYALEKISSPPQS-----------------------------ASSDSSQPIKNQDNTSNITVLV 102

Human   236 NDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAP- 299
            |.|.:.||..|       ...||...:.    :..|.|.|:..:|........||.|..:|..|
Frog   103 NGESSHATSSE-------LDVPAQDEAF----SNISSPLPSLGSELRSEDNEDTQSLQPSALTPT 156

Human   300 -DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTA 363
             :.||.|||||||.||||||||||||:||||||||.|||||.|.|||||||||||||||||||||
Frog   157 SEGLPPGWEQRELSNGRVYYVDHNTKSTTWERPLPLGWEKRVDNRGRFYYVDHNTRTTTWQRPTA 221

Human   364 EYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTR 428
            |||||||||||||||:|||||..|||||||.|||:.|:|||||||.|||||||||||||||||||
Frog   222 EYVRNYEQWQSQRNQMQGAMQQLSQRFLYQPSSAAPDNDPLGPLPNGWEKRQDNGRVYYVNHNTR 286

Human   429 TTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQ-GSPGAYD 492
            ||||||||||||||||||||||||||||||:|||||||.|.||||||||||:||.|| |||||||
Frog   287 TTQWEDPRTQGMIQEPALPPGWEMKYTSEGIRYFVDHNKRATTFKDPRPGFDSGVKQGGSPGAYD 351

Human   493 RSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYG 557
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   352 RSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYG 416

Human   558 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 622
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   417 GIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 481

Human   623 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHEL 687
            |||||||||||||||:|||:|||||||||||||:|||:||||||.|||||:|||||||:||:|:|
Frog   482 DTGFTLPFYKRMLNKKPTLRDLESIDPEFYNSIMWIKDNNLEECELELYFVQDMEILGEVTSHKL 546

Human   688 KEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGM 752
            |||||:||||||||||:|.|||||||||||||||.||||||.||.||||||||||||||||||||
Frog   547 KEGGENIRVTEENKEEFISLLTDWRFTRGVEEQTNAFLDGFKEVVPLEWLRYFDEKELELMLCGM 611

Human   753 QEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNG 817
            ||||::||||:||||||||||||:|||||||||||||||||||||||||||||||||.|||||||
Frog   612 QEIDIADWQKNTIYRHYTKNSKQVQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFVELIGSNG 676

Human   818 PQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
            |||||||:|||:||||||||||||||||||||||||:||||:|||||||||||
Frog   677 PQKFCIDRVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		27/154 (18%)
		Atrophin-1	<164..343	CDD:331285	63/187 (34%)
		WW	302..331	CDD:306827	25/28 (89%)
		WW	332..361	CDD:306827	25/28 (89%)
		WW	407..435	CDD:306827	26/27 (96%)
		WW	447..477	CDD:238122	26/29 (90%)
		HECTc	516..868	CDD:238033	327/351 (93%)
wwp2	NP_001090841.1	WW	160..189	CDD:366073	25/28 (89%)
		WW	190..219	CDD:366073	25/28 (89%)
		WW	265..293	CDD:366073	26/27 (96%)
		WW	305..335	CDD:238122	26/29 (90%)
		HECTc	375..727	CDD:238033	327/351 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	602	1.000	Domainoid score	I2404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48490
Inparanoid	1	1.050	1148	1.000	Inparanoid score	I2422
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		oto147922
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110