Protein Alignment WWP1 and Nedd4

DIOPT Version :9

• Sequence 1: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 1116
• Identity: 342/1116 - (30%)
• Similarity: 484/1116 - (43%)
• Gaps: 373/1116 - (33%)

Human     7 RSDTSNNHSG-RLQLQVTVSSAKLKRKKNWFGTA----------IYTEVVVDGEITKTAKSSSSS 60
            ||..:.|.|| ...|::.|.:.:...||:.||.:          |..::.:|..:|||.|  .:.
  Fly    58 RSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKK--KTL 120

Human    61 NPKWDEQLTVNVTP-QTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLE 124
            ||.|:|:....|.| :..|.|||:....|..|..||..
  Fly   121 NPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMV--------------------------- 158

Human   125 NKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGI 189
                     |||:|  .|..|||..|....|.|:             .|.....|:..::||..|
  Fly   159 ---------ELTLV--NLPTEQEGRTIGEQSYTL-------------RPRRSVGAKSRIKGTLRI 199

Human   190 DNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDN 254
            .:.....|..|                                  |||:....:||
  Fly   200 YHAFIRETREQ----------------------------------SEPSSGNSDGE--------- 221

Human   255 ASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSR 319
                      .|:..:.|...|:.:..|.
  Fly   222 ----------WEHVEATNAGETSAQPHPF------------------------------------ 240

Human   320 SSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP---- 380
                        |.|..|            .||:|||:|:|.:||||||:|..|||.|:||
  Fly   241 ------------PTGGHD------------ALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLN 281

Human   381 --------QPLPPGWERR----VDDR---RRVYYVDHNT-------------------------- 404
                    ..|...::||    |||.   |....:.||:
  Fly   282 SHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNT 346

Human   405 ---------------RTTTWQRPTME-----------------------SVRN------------ 419
                           |....|.||::                       |::|
  Fly   347 PTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVP 411

Human   420 -------FEQ-----------WQSQ--RNQLQGAMQQFNQRYLY--------------------- 443
                   |.:           ||.:  |.|:|..:||..||...
  Fly   412 DIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRG 476

Human   444 -------------------------------------SASMLAAENDPYG---PLPPGWEKRVDS 468
                                                 :|::...|.:..|   ||||.|..:|..
  Fly   477 QRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAP 541

Human   469 TDRVYFVNHNTKTTQWEDPR----------TQGLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTT 522
            ..|.:|::|.::.|.|.|||          |:.:::: .|||||||.|...:|..:::|||||||
  Fly   542 NGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTT 606

Human   523 TFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFR-YLCQSNALPSHVKINVSRQTLFEDSFQQIMA 586
            .::|||....::  .|..:.|.|.::.|..:|: ::.:...:|:..:|.:.|.::.|||::.|.:
  Fly   607 QWEDPRLSNPNI--AGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISS 669

Human   587 LKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI- 649
            :...| |:.:|:|.|.||.||||||||||||:|||.|:.||.|.||||:..:||.||||..|.:
  Fly   670 VTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLC 734

Human   650 NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNN 714
            |.:|||||.||||...||::|||.:|..|..||||.||.|.:.:||:||:|||:||||:||::|:
  Fly   735 NEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND 799

Human   715 IEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDG 779
            ...  ||:.|.:|.::.|:.:.|:||.||:||.||.|||||||.|:.||||...|:||..:||||
  Fly   800 PRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDG 862

Human   780 FNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVR 843
            |..::||..::.|||.|||:::||:|.:|:.||:.||:|: .|..|...|.|||:.|....||:|
  Fly   863 FGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMR 927

Human   844 MRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 908
            .|||||||||.|:|:.||.||.||||||.|.|||.|.....||:||||||||||||:.|.|||:|
  Fly   928 SRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDK 992

Human   909 LLFAIEETEGF 919
            |:.|||.::||
  Fly   993 LIKAIEGSQGF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	30/133 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		33/189 (17%)
		HUL4	<307..922	CDD:227354	284/804 (35%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	42/185 (23%)
		WW	248..277	CDD:278809	18/28 (64%)
		WW	531..560	CDD:278809	10/28 (36%)
		WW	581..613	CDD:197736	18/31 (58%)
		HECTc	650..1003	CDD:238033	191/354 (54%)
		HECTc	674..1003	CDD:214523	185/330 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10869
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.710