Protein Alignment WWP1 and Su(dx)

DIOPT Version :10

• Sequence 1: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 1001
• Identity: 511/1001 - (51%)
• Similarity: 638/1001 - (63%)
• Gaps: 159/1001 - (15%)

Human     3 TASPRSDTSNN-------HSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEI-TKTAKSSSS 59
            :|||...:|:.       :.|..||.||:..|.| |...:.....|.|:::|.:. .||....:|
  Fly    27 SASPTPTSSSGAGASGSANQGYHQLSVTIEEASL-RNNGFLKPNPYVELLIDSKSKRKTDLVKNS 90

Human    60 SNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLE 124
            ..|||:|:.||.:||.:||.|:|..|.:.:.||:||:..|:|...|..:|.:.|.::..:.|.:.
  Fly    91 YLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVT 155

Human   125 NKNGIAQT--GELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPS------------- 174
            :|:...||  |||..:|:||.::...:    ....:..|:||:...:...||
  Fly   156 SKSDNRQTKSGELVAILNGLKLDMSKL----QIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMI 216

Human   175 -ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSY-------------------------VVNGDNT 213
             ....||:.:..::|..|...|.:.:.|....:                         :|||..
  Fly   217 YGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSG- 280

Human   214 PSSPSQVAARPKNTPAP---KPLA---------SEPADDTVNGESSSFAPTDNASVTGTPVVSEE 266
             ::..|.|..|:..|||   :||.         ::||        :.:.|....:..|.|.|:
  Fly   281 -AAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPA--------AVYLPAGGGAAVGPPGVA-- 334

Human   267 NALSPNCTSTTVEDP----PVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAA 327
                    ...:|.|    ||.:            ||..:|::
  Fly   335 --------GPPIEQPGVGLPVSQ------------STDPQLQT---------------------- 357

Human   328 KSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVD 392
               ||             |:.|.||:|||.|.|.:||.||||||||:|.||:|.|||||||.|.|
  Fly   358 ---QP-------------ADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKD 406

Human   393 DRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASM 447
            .|.||||||||||.||||||..|.:.:|:.||.||..:   :.|.|||||||          |.:
  Fly   407 GRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQV 468

Human   448 LAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----LQNEEPLPEGWEIRYTR 508
            ...:.|..||||.||||::.|.:|||||||..:|||||||||||    |.||.|||.|||||||.
  Fly   469 TQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTA 533

Human   509 EGVRYFVDHNTRTTTFKDPRNGKSSVTKG--GPQIAYERGFRWKLAHFRYLCQSNALPSHVKINV 571
            .|.|:|||||||.|||:|||.|.....||  |...||||.|||||:.|||||||||||||:||.|
  Fly   534 AGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITV 598

Human   572 SRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGK 636
            :||||||||:.|||.|..|:||||||:||||||||||||::||||||||||||||||||||||.|
  Fly   599 TRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANK 663

Human   637 NNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDT 701
            |||.|||||||.:|||||.||.||||||||||:||:||.:||::|||||||:|||||||:|:||.
  Fly   664 NNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDP 728

Human   702 EFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFS 766
            ||||||||::||||:|||||::||||.|:||::..|:||..|....||||||:|||.||||||.:
  Fly   729 EFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMT 793

Human   767 RGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWF 831
            ||:::|||.||:||||||||:||:||||:|||::|||||:||:.||||||:||||.|||||::||
  Fly   794 RGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWF 858

Human   832 WQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDL 896
            ||||:|||||.|.|||||||||||:|:|||||||||||||:||||||||:|||||||||||||||
  Fly   859 WQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDL 923

Human   897 PPYKSYEQLKEKLLFAIEETEGFGQE 922
            ||||||:||.|||.|||||||||.||
  Fly   924 PPYKSYDQLVEKLTFAIEETEGFCQE 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	42/125 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		52/193 (27%)
		SP1-4_N	<236..>344	CDD:425404	15/111 (14%)
		HUL4	<307..922	CDD:227354	424/630 (67%)
		Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000269|PubMed:34404733	349..531		119/195 (61%)
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	42/125 (34%)
		WW	364..396	CDD:197736	21/31 (68%)
		HUL4	<395..946	CDD:227354	397/553 (72%)