Protein Alignment WWP1 and Hecw

DIOPT Version :10

• Sequence 1: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 1319
• Identity: 343/1319 - (26%)
• Similarity: 501/1319 - (37%)
• Gaps: 451/1319 - (34%)

Human     2 ATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDE 66
            ||.||    :|:::|.:......|.....|:|:|               |.:.:|..|:.....:
  Fly   161 ATLSP----TNSYNGSIGSDGGSSVGGGARRKSW---------------TLSPQSGGSTPLSGAK 206

Human    67 QLTVNVTPQTTLE------FQVWSHR------------TLK------------------ADALLG 95
            :.|....|.|||.      |.:|..|            ||.                  .::|||
  Fly   207 KKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLG 271

Human    96 KATI-----------------DLKQALLIHNRKLER------VKEQLKL---------------- 121
            .|..                 .|:|.....:|.|||      |...|||
  Fly   272 AAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERL 336

Human   122 --SLENKNGIAQTGELT---VVLDGLV---IEQENITNCSSSPTIEIQENGDALHENGE----PS 174
              .:...:|.:....|.   |....|:   |..::..|..|:..:.:       |::.|    ||
  Fly   337 AEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPV-------HQSYEFPTFPS 394

Human   175 ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAAR----PKNTPAP----K 231
            :.     ||..::...|.:....|.|:...:..::.....||..|.:.|    ||...:|    .
  Fly   395 SS-----AVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCS 454

Human   232 PLASEPADDTVNGESSSFAPTDNASV--------------------------------------- 257
            ..::.|.|.:::.|..|  ||....|
  Fly   455 TRSASPLDISLSPEQHS--PTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGG 517

Human   258 -TGTPVV------------SEENALSPNCT----STTVEDPPV------------------QE-- 285
             ||:|:|            :...|::.|.:    .....|||.                  ||
  Fly   518 ATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQS 582

Human   286 ---ILTSSENNECIPSTSAELESEA------RSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQ 341
               :..||.....||..||...:.|      .:::||.|.....||.
  Fly   583 DEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSG------------------ 629

Human   342 QSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPG------------WERRVDDR 394
             :|.|....||..||.|.|.|||.:|:||.||||:|:||...|.|            .:||....
  Fly   630 -AGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSI 693

Human   395 RR----------VYYV----DHNTRTTTWQRPTMESVRN-------FEQWQSQRNQLQGAMQQFN 438
            ||          :|.:    :.|..:|....|...:..:       ...:.|..:..:.|:..:|
  Fly   694 RRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYN 758

Human   439 -------------------QRYLYSASMLAAEN---DPYGPLPPGWEKRVDSTDRVYFVNHNTKT 481
                               |||.|:..::|..|   .....||..||.::|.:.:.:|::|..:.
  Fly   759 RNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRR 823

Human   482 TQWEDPR-------------------------------------TQGLQNEE---------PLP- 499
            |.:.|||                                     |.|..|..         |||
  Fly   824 TSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPP 888

Human   500 -------------------------------------------------EGWE---IRYTREGVR 512
                                                             .|:|   |.|..:.:.
  Fly   889 PRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIA 953

Human   513 YF---------------------------------------VDHNTRTTTF-------------- 524
            :.                                       :.|:.:.|..
  Fly   954 FLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPI 1018

Human   525 --KDPRNGKSSVTKGGPQIA---YERGFRWKLAHFRYLCQSNAL---PSHVKINVSRQTLFEDSF 581
              :.|: |...:....||.|   :.|.|..||..|....:|...   |..:|:::.|..|.||:|
  Fly  1019 EERSPQ-GSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAF 1082

Human   582 QQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINP 645
            ::||:....||:| ||.|::..||||||||.:||:|||||.|:.||.|.||||:..:.|.:|::|
  Fly  1083 RRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSP 1147

Human   646 ASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWI 710
            .|....:...:|.|.||.:.:||.|...:|..|:.||||.:|...:.:.||||:|.||:.||.||
  Fly  1148 LSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWI 1212

Human   711 RDNNI-EECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTK 774
            |||:| ....|.:.|.|..|:||.|...:||.||.||::.|:||.||:..|.:||..|||||||:
  Fly  1213 RDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTE 1277

Human   775 AFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKET 838
            :.:.||.||:..:.:..||.:|||:::.|..|:|..||:.||.||. |..|.:.|:||||.::..
  Fly  1278 SLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERF 1342

Human   839 DNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYE 903
            .||.|:|||||||||..:|..||:.|.||.||::|||||.||...|||:||||||||||||.:.|
  Fly  1343 SNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPE 1407

Human   904 QLKEKLLFAIEETEGFGQE 922
            .|.||||.|:|||..||.|
  Fly  1408 LLYEKLLLAVEETNTFGIE 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	34/202 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		60/282 (21%)
		SP1-4_N	<236..>344	CDD:425404	30/192 (16%)
		HUL4	<307..922	CDD:227354	258/838 (31%)
		Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000269|PubMed:34404733	349..531		62/390 (16%)
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	25/152 (16%)
		WW	638..667	CDD:459800	17/28 (61%)
		HECW1_helix	738..794	CDD:465766	9/55 (16%)
		HECTc	1068..1424	CDD:238033	175/355 (49%)