DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPSF6 and Cpsf6

DIOPT Version :9

Sequence 1:	XP_005268645.1	Gene:	CPSF6 / 11052	HGNCID:	13871	Length:	589	Species:	Homo sapiens
Sequence 2:	NP_648206.1	Gene:	Cpsf6 / 38937	FlyBaseID:	FBgn0035872	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	288/713 - (40%)
Similarity:	367/713 - (51%)	Gaps:	188/713 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     1 MADGVDHIDIYA-DVGEEFNQEA--EYGGHDQIDLYDDVISP--SANNGDAPEDRDYMDTLPPTV 60
            |||.|  :|:|| |:.::|..:|  |:|| |.:|||||:..|  ||.:|.....       .|:.
  Fly     1 MADVV--LDLYAEDLDKDFAGQAQDEFGG-DGVDLYDDIGGPTESAASGGGGGG-------TPSA 55

Human    61 GDDVGKGA---------APNVVYTYT--------GKRIALYIGNLTWWTTDEDLTEAVHSLGVND 108
            ....|.|:         .||.||..:        .:|..||:|||||||||:|:..::..:||:|
  Fly    56 DGAAGPGSGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNLTWWTTDQDIANSLRDIGVSD 120

Human   109 ILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFE-MQSR 172
            :.|:||||||||||||||:::.:|||:|.:.::|.|||:|:|||.||||..:||.|:||| :|..
  Fly   121 LQEVKFFENRANGQSKGFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQKT 185

Human   173 KTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPGNLIKH 237
            :.....|.:     |||.|.:..:.     |.|..|...|||.:..||  ||.||
  Fly   186 RPVPPPQQN-----GPPRGPAPPSM-----GGGPMPTGHPGGPQGGGP--PGHPP---------- 228

Human   238 LVKGTRPLFLETRI-PWHMGHSIEEIP-IFGLKAGQTPPR--PPLGPPGP-PGPPGPPP------ 291
              :|...:....:. |.||    .::| :.|..:|  |||  ||:.|.|. .|...|||
  Fly   229 --RGMNSIMQPGQYRPQHM----SQVPQVGGPNSG--PPRMQPPMHPQGGLMGNQQPPPRYPSAQ 285

Human   292 ---PGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPP---PPVPGYGPPPGPPPPQ 350
               |||....|..||||   .||...:|.|.|.|.|..|  |.||.   ||:.|..||.|||
  Fly   286 GQWPGQRPGGPRPGPPN---GPPQRPMFQGGPMGMPVRG--PAGPDWRRPPMHGGFPPQGPP--- 342

Human   351 QGPPPPPGPFPP--------------RPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPP 401
            :|.||.|||..|              :|.||       |..|.:.|||.|||.|.|.:|   .||
  Fly   343 RGLPPAPGPGGPHGAPAPHVNPAFFNQPGGP-------AQHPGMGGPPHGAPGPQPGMN---MPP 397

Human   402 PTNSGMPTSDSRGPPPT----DPYGR-PPPYDRGDYGPPGREMDTAR--TPLSEAEFEEIMNRNR 459
              ..||..:...||||.    .|.|. |||..:    |||...|..:  ..|:|.||||:|:|||
  Fly   398 --QQGMNMTPQHGPPPQFAQHGPRGPWPPPQGK----PPGPFPDPQQMGPQLTEVEFEEVMSRNR 456

Human   460 AISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYG- 523
            .:|||||:||||||:||:|.||||||||||||||||||:.|:|||:|||||||.|||||:|||.
  Fly   457 TVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDERCKILISSLQDTLHGIEAKSYNR 521

Human   524 -------------------SGSRRRERSRERDHSRSREKSR-----RHKSRSRDRH---DDYYRE 561
                               |.||.|||||||:..|.||:.|     |.:||||:|.   .|:||:
  Fly   522 RERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGSYRERSRSRERERQAPDHYRD 586

Human   562 RSR--------------------------ERERH---------RDRDRDRDRERDREREYRHR 589
            .||                          :|||:         |||||||:|||||:|...||
  Fly   587 DSRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRDRREEHR 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPSF6	XP_005268645.1	RRM	9..>152	CDD:223796	67/164 (41%)
CPSF6	XP_005268645.1	RRM_CFIm68	82..158	CDD:410048	45/75 (60%)
Cpsf6	NP_648206.1	RRM_CFIm68	94..170	CDD:241087	45/75 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143503
Domainoid	1	1.000	270	1.000	Domainoid score	I1845
eggNOG	1	0.900	-	-		E1_KOG4849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I2017
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48498
OrthoDB	1	1.010	-	-		D1016696at2759
OrthoFinder	1	1.000	-	-		FOG0003643
OrthoInspector	1	1.000	-	-		otm41467
orthoMCL	1	0.900	-	-		OOG6_108776
Panther	1	1.100	-	-	LDO	PTHR23204
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4521
SonicParanoid	1	1.000	-	-		X2511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890