DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UPK1A and Tsp74F

DIOPT Version :9

Sequence 1:	NP_001268372.1	Gene:	UPK1A / 11045	HGNCID:	12577	Length:	273	Species:	Homo sapiens
Sequence 2:	NP_524132.1	Gene:	Tsp74F / 39995	FlyBaseID:	FBgn0036769	Length:	236	Species:	Drosophila melanogaster

Alignment Length:	198	Identity:	42/198 - (21%)
Similarity:	79/198 - (39%)	Gaps:	32/198 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    20 LVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGA-WIAIFCGFSFFMVASFGVG 83
            |.:.|.:|.:.|..:|..|:|...|:..|..|:|.    ::|:|| ::.:.......:|:..|..
  Fly    18 LFIANFVIFVGGAIVFCLTLWTLVDRSFVNELLGT----NLFSGAVYVLLVTSIIICLVSFLGCV 78

Human    84 AALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTR 148
            .|....:.::|||.:::.:|::......:..|..|:.:........:..:..|.:    .:|:|:
  Fly    79 GAGKEVKCLLLTYFIIVALVFVTMLIGGVLGYVFRERVQQTMRQEMRSTMALYGS----RREITQ 139

Human   149 LWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCC-------RRTGNFIP----LNE 202
            .||......:|||.....||..:.            |.|..||       |:.....|    |..
  Fly   140 AWDLTQERLQCCGVDTWHDWNRYG------------PVPESCCQELFGGQRKECTIFPTITNLYN 192

Human   203 EGC 205
            :||
  Fly   193 QGC 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UPK1A	NP_001268372.1	uroplakin_I_like_LEL	112..216	CDD:239409	21/105 (20%)
Tsp74F	NP_524132.1	Tetraspannin	14..231	CDD:395265	42/198 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19282
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910