DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STON1 and stnB

DIOPT Version :9

Sequence 1:	NP_001185524.1	Gene:	STON1 / 11037	HGNCID:	17003	Length:	735	Species:	Homo sapiens
Sequence 2:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	193/844 - (22%)
Similarity:	326/844 - (38%)	Gaps:	204/844 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    13 DDDPAVQSSQKSKNFPLENQGVCRPNGLKLNLPGLREFPSGSSSTSSTPLSSPIVDFYFSPGPPS 77
            |.:|.:.|........|..|.......|....|...|..:|        |..|:.    |.|..|
  Fly   439 DTEPEIVSEHSPPTERLVTQAALVDGELIAAEPEPEEMDTG--------LDFPLA----SSGQLS 491

Human    78 NSPLSTPTKDFPGFPGIPKAGTHVLYPI--PESSSDSPLAIS----------------------- 117
            .:|.::|.::.|.|..:|.|..:: :.:  |:|..::|.|.|
  Fly   492 ANPFASPDEEEPNFAPMPAAVANI-FAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSV 555

Human   118 -----------GGESSLLPTRPTCLSHALLPSDHSCTHPTPKVGLPDEVNPQQAESLGFQSDDLP 171
                       ||..::.||.......:...|.....:........|:         ||.:||
  Fly   556 KKDNISIMDGFGGSGAITPTGGDAWGGSAFGSTTISANACGDTNSADD---------GFGNDD-- 609

Human   172 QFQYFREDCAFSSPFWKDEGSDSHFTLDPPGSKKMFSSRNKEMPIDQKSLNKCSLNYICEKLEHL 236
                                 |..:.:..|.......|.:|:..:..:.:.:.:.....:.....
  Fly   610 ---------------------DDFYAMQAPARADSVESVDKDFSVVIRPMAEETSGVAPQLAPPP 653

Human   237 QSAENQDSLRSLSMHCLCAE--ENASSF--------------------VPHT-LFR---SQPKS- 274
            ..|...:..::.|:..|...  |:.|.|                    .|.| |:.   |||..
  Fly   654 PPARGVNQAQTTSLPGLTVNPFEDVSGFPAPGLPPTDGTAIKRTDSQDTPQTPLYDEDVSQPLEE 718

Human   275 ---------GWSFMLRIPEKKNMMSSRQWGPIFLKVLPGG---ILQMYYEQGLEKPFKEIQLDPY 327
                     ||...||.|.||.:...|.|..|.::::...   ::|:..:.|.::||:|:.|.|.
  Fly   719 FPRLHYIGPGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPS 783

Human   328 CRLSEPKVENFSVAGKIHTVKIEHVSYTEK---------------------------------RK 359
            ..:||...:.:...|||.|:|::::.|.|:                                 ::
  Fly   784 YSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKE 848

Human   360 YHSKTE-----VVHEPDIEQMLKLGSTSYHDFLDFLTTVEEELMKLPAVSKPKKNYEEQEISLEI 419
            :.|..:     |.|.|...|:.|:||.:|.|...|...:||.|.|:||:.:....|:.:|:.:..
  Fly   849 FGSDLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPALRERALTYKMEEVQVTA 913

Human   420 VDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDESYYEKDSEKKGIDILD 484
            ||....:...|||.::.....:::.|.|:.|.....|.:||:              .::|.:::.
  Fly   914 VDEITVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVNDM--------------WRQGKEVVG 964

Human   485 YH-----------------FHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTL-YNGDNLPFSLK 531
            .|                 ||..||.:|:|::|.|||.|.||...||:||:.. .....||..||
  Fly   965 RHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLK 1029

Human   532 SVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQRQKSLKAK 596
            :...|.|..|||:|.:.:.....|.  .|.: .|:::.:.||:|..||.........|..|:|:.
  Fly  1030 ATWCVSGNKVELRADILVPGFTSRK--LGQI-PCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSA 1091

Human   597 MNR-------RACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYK 654
            ..|       ...||::..|: |.:|:||.|.||||..::|:||:..|||.:.......|.|..:
  Fly  1092 HRRTGKIKGIERILGAVDTLQ-ESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCR 1155

Human   655 LELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGV---ESDVQPQKHVQQRACYNIQVEIE 715
            :.|.|..:|||:..|:|.|:|::|.|..|.|.|||:.|   :.|..|:|:|:..|.:..:|.||
  Fly  1156 MALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLARHEYKVGIE 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STON1	NP_001185524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		5/21 (24%)
STON1	NP_001185524.1	AP_stonin-1_MHD	403..716	CDD:271168	99/341 (29%)
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603	15/68 (22%)
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	97/339 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3417
eggNOG	1	0.900	-	-		E1_KOG2677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.940