DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GTF2A1L and TfIIA-L

DIOPT Version :9

Sequence 1:	NP_006863.2	Gene:	GTF2A1L / 11036	HGNCID:	30727	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_476995.1	Gene:	TfIIA-L / 43284	FlyBaseID:	FBgn0011289	Length:	366	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	145/482 - (30%)
Similarity:	221/482 - (45%)	Gaps:	125/482 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     3 CLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATE---DFFRNSIQSP 64
            |...|.|:|.:||||||..||:.|.:||::||||:::||:|..|:|.|||.|   |....|...|
  Fly     4 CQTSVLKVYHAVIEDVITNVRDAFLDEGVDEQVLQEMKQVWRNKLLASKAVELSPDSGDGSHPPP 68

Human    65 LFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVS 129
            : ....|.| |:...:...........|    :...:|.::|.::.            |.|::.:
  Fly    69 I-VANNPKS-HKAANAKAKKAAAATAVT----SHQHIGGNSSMSSL------------VGLKSSA 115

Human   130 GHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVL 194
            |         |...:..|.|::  ||:|        .|...:.|.|:|.|..:..:|.
  Fly   116 G---------MAAGSGIRNGLV--PIKQ--------EVNSQNPPPLHPTSAASMMQKQ------- 154

Human   195 QQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSN 259
            ||.|....|.:.           :|:..:.::|:|.          .|:||    ||
  Fly   155 QQAASSGQGSIP-----------IVATLDPNRIMPV----------NITLP----SP-------- 186

Human   260 VESVLSGSASMAQNLHDESLSTSPHGALHQH-VTDI-QLHILKNRMYGCDSVKQPRNIEEPSNIP 322
                 :||||....:....:   |..||.:: :|.| ..|::.:.|            ..|:.:.
  Fly   187 -----AGSASSESRVLTIQV---PASALQENQLTQILTAHLISSIM------------SLPTTLA 231

Human   323 VSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDL-KVPEE 386
            .|....:....||.......:....|:||:.|:|..:|   :.::|:|  :.|.|..|| |..:|
  Fly   232 SSVLQQHVNAALSSANHQKTLAAAKQLDGALDSSDEDE---SEESDDN--IDNDDDDDLDKDDDE 291

Human   387 EADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKW 451
            :|:   :||:|              ||:||||.|||:::|..::||||||||||||||.||:|||
  Fly   292 DAE---HEDAA--------------EEEPLNSEDDVTDEDSAEMFDTDNVIVCQYDKITRSRNKW 339

Human   452 KFYLKDGVMCFGGRDYVFAKAIGDAEW 478
            |||||||:|...|:||||.|:.|||||
  Fly   340 KFYLKDGIMNMRGKDYVFQKSNGDAEW 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GTF2A1L	NP_006863.2	TFIIA	10..478	CDD:308659	140/473 (30%)
GTF2A1L	NP_006863.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..427		31/118 (26%)
TfIIA-L	NP_476995.1	TFIIA_alpha_beta_like	8..>62	CDD:199899	28/53 (53%)
		TFIIA	11..366	CDD:281188	140/473 (30%)
		TFIIA_alpha_beta_like	<306..366	CDD:199899	41/59 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2652
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1443035at2759
OrthoFinder	1	1.000	-	-		FOG0002746
OrthoInspector	1	1.000	-	-		otm41527
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12694
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X1433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.930