DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and BCK1

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	340	Identity:	85/340 - (25%)
Similarity:	147/340 - (43%)	Gaps:	55/340 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    15 LVSIEELENQ------------ELVGKGGFGTVFRAQHRKWGYDVAVKIV--------------N 53
            :|||.:.:|.            |::|||.||.|:...:...|..:|||.|              .
Yeast  1157 MVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILST 1221

Human    54 SKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLC 118
            .:|:..||..:..||:..:::..|...|.|     ..:|..:::..||:..|::.......||:.
Yeast  1222 VEALRSEVSTLKDLDHLNIVQYLGFENKNN-----IYSLFLEYVAGGSVGSLIRMYGRFDEPLIK 1281

Human   119 RLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTL 183
            .|..:|:.|:.|||.:.  :||||:|..|:|||.:...|::|||:|.......|.:.. ...||:
Yeast  1282 HLTTQVLKGLAYLHSKG--ILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDM-TMRGTV 1343

Human   184 GYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAE--LP 246
            .::|||: |:..:..|...|::|.|.::..:.||:......|.......:...::.|.:.|  ||
Yeast  1344 FWMAPEM-VDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLP 1407

Human   247 ---QAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFL--- 305
               |.|         :..:..|:...|:.||:..|.|   ...|..|....|...:.:..|:
Yeast  1408 LISQIG---------RNFLDACFEINPEKRPTANELL---SHPFSEVNETFNFKSTRLAKFIKSN 1460

Human   306 SQLRSSNRRFSIPES 320
            .:|.||..|.:..|:
Yeast  1461 DKLNSSKLRITSQEN 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	72/288 (25%)
		PKc_like	27..280	CDD:304357	70/271 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	72/287 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910