DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and SWE1

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_012348.1	Gene:	SWE1 / 853252	SGDID:	S000003723	Length:	819	Species:	Saccharomyces cerevisiae

Alignment Length:	378	Identity:	92/378 - (24%)
Similarity:	159/378 - (42%)	Gaps:	94/378 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    19 EELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NS-KAISREVKAMASLDNEFVLRLEG 77
            |:..|...:|||.|.||::....:.....|:|.:     || |.|..|:|.:..:.|:..:..||
Yeast   442 EKFTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNSLKRILLEIKILNEVTNQITMDQEG 506

Human    78 ---VIEKV-NWDQDPKPALVTKFMENGSLSGLLQSQCP---------RPWPLLCRLLKEVVLGMF 129
               :|:.: :|.......::|:..|||:|.|.||.|..         |.|    :::.|:.|.:.
Yeast   507 KEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWRIW----KIIVELSLALR 567

Human   130 YLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLST---FQGGSQSGTGSGEPGGTLGYLAPELF 191
            ::||...: :|.||||:||::..|.::||.|||::|   .:..|....|..|      |:|||:.
Yeast   568 FIHDSCHI-VHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENEGDRE------YIAPEII 625

Human   192 --VNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPG 254
              ...:.||    |::|.|:::..:.|  .|.||...        |..::....:|..||..:
Yeast   626 SDCTYDYKA----DIFSLGLMIVEIAA--NVVLPDNG--------NAWHKLRSGDLSDAGRLS-- 674

Human   255 LEGLKELMQLCWSSEPKDRPSFQECLP-KTDEVFQMVENNM-----NAAVSTVKDFLSQLRSSNR 313
                        |::......|.:... .|:::|....:|:     ||..|||        .:|.
Yeast   675 ------------STDIHSESLFSDITKVDTNDLFDFERDNISGNSNNAGTSTV--------HNNS 719

Human   314 RFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEP---PSSVPK 363
            ..:.|              .:.|.:..|:|..:...|:|.|.:.   |:.|||
Yeast   720 NINNP--------------NMNNGNDNNNVNTAATKNRLILHKSSKIPAWVPK 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	71/281 (25%)
		PKc_like	27..280	CDD:304357	70/276 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		4/12 (33%)
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
SWE1	NP_012348.1	PTKc_Wee1_fungi	443..791	CDD:270954	91/377 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5963
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950