DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and slpr

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	139/576 - (24%)
Similarity:	218/576 - (37%)	Gaps:	161/576 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA----------ISREVKAMASLDNE 70
            :...||:.:|::|.|||..|.|..:.  |.:||:||.:...          :.:|.|...:|.:|
  Fly   124 IEYNELDIKEVIGSGGFCKVHRGYYD--GEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHE 186

Human    71 FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP----WPLLCRLLKEVVLGMFYL 131
            .:..|.||.      .:.|..||.::...|||:.:|..:.|..    |.:      ::..||.||
  Fly   187 NIAALRGVC------LNTKLCLVMEYARGGSLNRILAGKIPPDVLVNWAI------QIARGMNYL 239

Human   132 HDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQGGSQSGTGSGEPGGTLGYLA 187
            |::.|: ::|||||.||||:...:.        :|:.||||:.....:|..:.:    ||..::.
  Fly   240 HNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA----GTYAWMP 300

Human   188 PELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP-SLVYEAVCNRQNRPSLAELPQAGPE 251
            ||: ::|: ..|..|||:|:|:|:|.::.|.......:| |:.|....|....|    :|:..||
  Fly   301 PEV-ISVS-TYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLP----IPKTCPE 359

Human   252 TPGLEGLKELMQLCWSSEPKDRPSFQECLPKTD------------EVFQMVENNMNAAVSTVKDF 304
            |.|     .||:.||.::|..||.|:|.|.:.:            |.|..::......::.|
  Fly   360 TWG-----ALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGV--- 416

Human   305 LSQLRSSNRRFSIPESGQGGTEMDGFRRTIE-------------NQHSRNDVMVSEWLNKLNLEE 356
            |..||...:||...|......|....|...|             |...|..|::...|  :.|:.
  Fly   417 LHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL--VMLQP 479

Human   357 PPSSVPKKCPSLTK-----------------RSRAQEEQVP----------------QAWTAGT- 387
            .||....|.....|                 |.:|::...|                :.|...|
  Fly   480 VPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTM 544

Human   388 ---------SSDSMAQPPQTPETSTF----------------RNQMPSPTSTGTPSPGPRGNQGA 427
                     |..|..||....:|||.                :||....:.|..|..|..|..|
  Fly   545 HQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSG- 608

Human   428 ERQGMNWSCRTPEPNPVTGRPLV-------NIYNCSGVQVGDNNYLTMQQTTALPT 476
               |...:..||...|  |.|::       ||.||..:..      |:..||...|
  Fly   609 ---GAGGTPATPLLYP--GIPIILTRPNNNNIGNCKAITT------TITTTTTTTT 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	82/281 (29%)
		PKc_like	27..280	CDD:304357	81/276 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		26/146 (18%)
		RHIM	419..468	CDD:289491	13/55 (24%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518		1/1 (100%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	84/285 (29%)
		STKc_MLK	134..389	CDD:270963	82/283 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810