Protein Alignment RIPK3 and Takl2

DIOPT Version :10

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_651090.2
• Gene: Takl2 / 42692
• FlyBaseID: FBgn0039015
• Length: 281
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 83/286 - (29%)
• Similarity: 131/286 - (45%)
• Gaps: 49/286 - (17%)

Human    11 APAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV----NSKAISREVKAMASLDNEF 71
            ||...|..||::.:||:|.|.:|:|:||..|  ..::|:|.:    ..|.|.||:..:....:..
  Fly     3 APVEGVPYEEIQTKELIGTGFYGSVYRAVWR--NREIALKRIREGCEDKKIEREIYQLTKASHVN 65

Human    72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP---------WPLLCRLLKEVVLG 127
            ::.|.|...     .:....|:.:|::.||||..|.:: .:|         |      ..::..|
  Fly    66 IVELYGTSR-----HEGCALLLMEFVDGGSLSSFLHAK-SKPSYSHAHAFNW------AHQIAQG 118

Human   128 MFYLHDQNP-VLLHRDLKPSNVLL-DPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPEL 190
            :.|||...| .::|||:||.|.|| :..|.:|:.|||  |....|||.:.:   .||..|.|||
  Fly   119 IAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFG--TVVDLSQSISCN---AGTCRYKAPE- 177

Human   191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP--SL--VYEAVCNRQNRPSLAELPQAGPE 251
             |....|.....||||:.|..|.:|:.:|   |.|.  :|  :|.|: |...||.|:.:....|
  Fly   178 -VLQGNKPDEKCDVYSWAITFWEILSRKE---PFEQYNTLFELYMAI-NEGERPDLSCIMSGCP- 236

Human   252 TPGLEGLKELMQLCWSSEPKDRPSFQ 277
                ..:..|:...|..:...|.|.:
  Fly   237 ----ADIVALLYASWDPDISKRFSME 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	Protein Kinases, catalytic domain	27..280	CDD:473864	76/270 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443
		RHIM	448..468	CDD:463679
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
Takl2	NP_651090.2	Protein Kinases, catalytic domain	19..268	CDD:473864	76/270 (28%)