Protein Alignment RIPK3 and Lrrk

DIOPT Version :10

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 107/466 - (22%)
• Similarity: 171/466 - (36%)
• Gaps: 134/466 - (28%)

Human    26 LVGKGGFGTVFRAQHRKWG----YDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQ 86
            |:|:|.||.||:|..:..|    ..||:|::.........|..|      ::..:..:.|  ||:
  Fly  1801 LLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESA------LMAFKVAVGK--WDR 1857

Human    87 DP----------------------------------KP-ALVTKFMENGSLSGLLQ-------SQ 109
            ||                                  || |||.:....|.|..||:       ..
  Fly  1858 DPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHM 1922

Human   110 CPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLL----------DPE--LHVKLADFG 162
            .|..:.   .|:.:....:.|||.:.  :::||||..|||:          .|.  :|:|:||:|
  Fly  1923 GPHTFQ---TLVLQAARAIEYLHRRR--IIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYG 1982

Human   163 LSTFQGGSQSGTGSGEPGGTLGYLAPELF-VNVNRKASTASDVYSFGILMWAVLAGREVELPTEP 226
            :|.    ..:.:|:...|||.|::|||:. .|...:.:...|.:|||:.::..::.|:   |.|.
  Fly  1983 ISR----QTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQ---PFEG 2040

Human   227 SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRP---------SFQECLPK 282
            ....:......:||:|.:     .||.......:||.|||..:|:.||         |..||:..
  Fly  2041 HESIKECILEGSRPALTQ-----RETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHL 2100

Human   283 TDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSE 347
            .|.|.......:...|     |.|.:            |.|..|..|....:.:..||.|::...
  Fly  2101 LDVVAMPHSEKIVCGV-----FQSLV------------GMGDDERCGLELWLPSFGSRIDILDCS 2148

Human   348 ------WLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQ-VPQ------------AWTAGTSSDSMA 393
                  ..|.::....|...|.|.|.....|||:..| :|:            .|....|.:..|
  Fly  2149 PSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHA 2213

Human   394 QPPQTPETSTF 404
            .     .|||:
  Fly  2214 Y-----STSTY 2219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	Protein Kinases, catalytic domain	27..280	CDD:473864	77/320 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443		15/63 (24%)
		RHIM	448..468	CDD:463679
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	77/318 (24%)