Protein Alignment RIPK3 and ksr

DIOPT Version :10

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_524236.2
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 83/286 - (29%)
• Similarity: 131/286 - (45%)
• Gaps: 51/286 - (17%)

Human    25 ELVGKGGFGTVFRAQHRKWGYDVAVKIVNS---------KAISREVKAMASLDNEFVLRLEGVIE 80
            |.:|:|.||||.||   .|..|||||::|.         :....||....:..:|.::...|...
  Fly   683 ERIGQGRFGTVHRA---LWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACM 744

Human    81 KVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLL---KEVVLGMFYLHDQNPVLLHRD 142
                 ..|..|:||...:..:|...:..:  |....:.|.|   :::..||.|||.:.  ::|:|
  Fly   745 -----NPPYLAIVTSLCKGNTLYTYIHQR--REKFAMNRTLLIAQQIAQGMGYLHARE--IIHKD 800

Human   143 LKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKA--------S 199
            |:..|:.:: ...|.:.||||.:.........|.|.|...|.||||||...:..:.        :
  Fly   801 LRTKNIFIE-NGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFT 864

Human   200 TASDVYSFGILMWAVLAGREVELPTEP--SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELM 262
            ..|||||||.:.:.::.| |.....:|  |::::.  .|..:.|||.| |:|.:      :|:|:
  Fly   865 PYSDVYSFGTVWYELICG-EFTFKDQPAESIIWQV--GRGMKQSLANL-QSGRD------VKDLL 919

Human   263 QLCWSSEPKDRPSFQ------ECLPK 282
            .|||:.|.:.||.|.      |.|||
  Fly   920 MLCWTYEKEHRPQFARLLSLLEHLPK 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	Protein Kinases, catalytic domain	27..280	CDD:473864	79/280 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443
		RHIM	448..468	CDD:463679
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
ksr	NP_524236.2	SAM_KSR1_N	33..86	CDD:466555
		SAM_KSR1	92..166	CDD:463916
		C1_KSR	370..418	CDD:410362
		PK_KSR	678..946	CDD:270965	83/286 (29%)