DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and wnd

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	136/484 - (28%)
Similarity:	207/484 - (42%)	Gaps:	107/484 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    14 PLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGV 78
            |..||.||   |.:|.|..|.||..  |.....||||.| .:....::|.:..||:|.:::.:||
  Fly   157 PFESITEL---EWLGSGAQGAVFSG--RLKNETVAVKKV-KELKETDIKHLRKLDHENIIKFKGV 215

Human    79 IEKVNWDQDPKPALVTKFMENGSLSGLL-QSQCPRPWPLLCRLL---KEVVLGMFYLHDQNPVLL 139
            .     .|.|...::.:|...|.|..:| :.|...|    .||:   |::.|||.|||...  ::
  Fly   216 C-----TQSPVFCIIMEFCPYGPLQNILKEEQVMLP----SRLVSWSKQIALGMQYLHSHK--II 269

Human   140 HRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDV 204
            |||||..|:|:.....||::|||  |.:..::..|.... .||:.::|||  |..|...|...|:
  Fly   270 HRDLKSPNILISTNEVVKISDFG--TSREWNEISTKMSF-AGTVAWMAPE--VIRNEPCSEKVDI 329

Human   205 YSFGILMWAVLAGREVELP---TEPSLVYEAVCNRQNRPSLAEL-PQAGPETPGLEGLKELMQLC 265
            :|:|:::|.:|.   .|:|   .:.|.:...|.|.    ||..| |...|     ||.|.|::||
  Fly   330 WSYGVVLWEMLT---CEIPYKDVDSSAIIWGVGNN----SLKLLVPSTCP-----EGFKLLVKLC 382

Human   266 WSSEPKDRPSFQECLPKTD----EVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTE 326
            |.|:|::||||::.|...|    |:.:..|...   ..|.|.:..::||     .:.|..|.||.
  Fly   383 WKSKPRNRPSFRQILSHLDIAGPELLRKTEKQY---FETQKSWKEEVRS-----HLKEITQNGTN 439

Human   327 MDGF------RRTIENQHSRNDVMVSE-WLNKLN-----LEEPPSSVPKKCPSLTKRSRA----- 374
            :..:      |||.|.:|:::..||.| .|.|.|     |.|..|.:.:|...:.:|.|.
  Fly   440 IHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKLPGSG 504

Human   375 ----------------QEEQVPQAWTAGTSSDSMAQPPQTPET-----------------STFRN 406
                            ...::..|..|.....:...|..|||:                 |...|
  Fly   505 YKPNRRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLAN 569

Human   407 QMPSPTSTGTPSPGPRGNQGAERQGMNWS 435
            .:|   |:|..:|.|..|:...|...|.|
  Fly   570 IIP---SSGLGAPMPNKNKKVFRHRRNAS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	85/265 (32%)
		PKc_like	27..280	CDD:304357	84/260 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		22/119 (18%)
		RHIM	419..468	CDD:289491	6/17 (35%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
wnd	NP_649137.3	STYKc	161..400	CDD:214568	89/272 (33%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	86/266 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910