Protein Alignment RIPK3 and LIMK1

DIOPT Version :10

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 121/486 - (24%)
• Similarity: 187/486 - (38%)
• Gaps: 107/486 - (22%)

Human    12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN------SKAISREVKAMASLDNE 70
            |..:....:|...|.:|:|.||.||:..||:.|..:.:|.::      .:...:||..:..||:.
  Fly   392 PQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHR 456

Human    71 FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCP-RPWPLLCRLLKEVVLGMFYLHDQ 134
            .||:..||:.|     |.|..:||:::..|.|..|:..... .|||...||.:::..||.|||..
  Fly   457 HVLKFIGVLYK-----DKKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSM 516

Human   135 NPVLLHRDLKPSNVLLDPELHVKLADFGL------------STFQGGSQSGTGSG---EPGGTLG 184
            |  ::||||...|.|:..:..|.:|||||            :...||..||..|.   .|.|||.
  Fly   517 N--IIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLR 579

Human   185 ------------------YLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP----- 226
                              ::|||:...:  |.....||:||||::..::...|.:....|
  Fly   580 RSKSRQRRQRYTVVGNPYWMAPEMMKGL--KYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDF 642

Human   227 SLVYEAVCNRQ--NRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVF-Q 288
            ||      |:|  .....|:.|         |...::..:|....|..||.|:     |..|: |
  Fly   643 SL------NQQEFREKFCAQCP---------EPFVKVAFVCCDLNPDMRPCFE-----TLHVWLQ 687

Human   289 MVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSE-WLNKL 352
            .:.:::.|.....:..|.::.:....::..|.....|.........|...|..|..:|. ...|.
  Fly   688 RLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEKE 752

Human   353 NLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSM----------AQPPQ---TPETSTF 404
            |:...|..:||. |.|.|......|::         .|||          ||..:   ||:|.:.
  Fly   753 NMVIKPQDIPKS-PHLGKDFSPSGERL---------RDSMRARRRQRFLGAQEERRNLTPDTESK 807

Human   405 RNQMPSPTSTGTPSPGPRG-----NQGAERQ 430
            ...:........|. |.||     ..|||.|
  Fly   808 ERALKKALKKCRPF-GERGYLVDLRAGAELQ 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	Protein Kinases, catalytic domain	27..280	CDD:473864	82/299 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443		23/94 (24%)
		RHIM	448..468	CDD:463679
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236
		STKc_LIMK	407..693	CDD:271056	85/314 (27%)