DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RIPK3 and Takl1

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_732554.1	Gene:	Takl1 / 318725	FlyBaseID:	FBgn0046689	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	87/335 - (25%)
Similarity:	152/335 - (45%)	Gaps:	59/335 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    23 NQELVGKGGFGTVFRAQHRKWGYDVAVKIVN------SKAISREVKAMASLDNEFVLRLEGVIEK 81
            :::.:|.|..|.|.:|..:  ..::||||.:      .|...||:..::.:|:|.|:|:.|
  Fly    13 SEKFLGAGSGGAVRKATFQ--NQEIAVKIFDFLEETIKKNAEREITHLSEIDHENVIRVIG---- 71

Human    82 VNWDQDPKPALVTKFMENGSLSGLLQ---------SQCPRPWPLLCRLLKEVVLGMFYLHDQNPV 137
             ......|..|:.:::|.|||...|.         .|..| |.|.|      ...:.|||..:..
  Fly    72 -RASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVR-WALQC------AKALAYLHSLDRP 128

Human   138 LLHRDLKPSNVLL-DPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTA 201
            ::|||:||.|:|| :....:|:.||||:|....:::     :..|||.|:|||...::  |.:..
  Fly   129 IVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKT-----DMQGTLRYMAPEAIKHL--KYTAK 186

Human   202 SDVYSFGILMWAVLAGR----EVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELM 262
            .|||||||::|.::..:    .:|.|.....:.:|:.:.:      :||.....:...||:|:||
  Fly   187 CDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGE------KLPMEAVRSDCPEGIKQLM 245

Human   263 QLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSN---RRFSIPESGQGG 324
            :.|....|:.|||.:|......|.::.         .|.:||:..|....   ..:.:..||...
  Fly   246 ECCMDINPEKRPSMKEIEKFLGEQYES---------GTDEDFIKPLDEDTVAVVTYHVDSSGSRI 301

Human   325 TEMDGFRRTI 334
            ..:|.:|..:
  Fly   302 MRVDFWRHQL 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	78/276 (28%)
		PKc_like	27..280	CDD:304357	78/272 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	77/273 (28%)
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	79/292 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810