DRSC/TRiP Functional Genomics Resources

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Protein Alignment RIPK3 and Raf

DIOPT Version :10

Sequence 1:NP_006862.2 Gene:RIPK3 / 11035 HGNCID:10021 Length:518 Species:Homo sapiens
Sequence 2:NP_525047.1 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster


Alignment Length:332 Identity:98/332 - (29%)
Similarity:147/332 - (44%) Gaps:63/332 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    19 EELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSK--------AISREVKAMASLDNEFVLRL 75
            ||:.....:|.|.||||:||.   |...||||.:|.|        |...||..:....:..:|..
  Fly   427 EEILIGPRIGSGSFGTVYRAH---WHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLF 488

Human    76 EGVIEKVNWDQDPKPALVTKFMENGSL-SGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLL 139
            .|.:.|      |..|:||::.|..|| ..:..|:.......|..:.::|..||.|||.:|  ::
  Fly   489 MGCVSK------PSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKN--II 545

Human   140 HRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELF-VNVNRKASTASD 203
            |||||.:|:.|..:|.||:.||||:|.:........:.:|.|::.::|||:. :......|..||
  Fly   546 HRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSD 610

Human   204 VYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQN----------RPSLAELPQAGPETPGLEGL 258
            ||:|||:|:.:||         ..|.|..:.|:..          ||.::::....|     :.|
  Fly   611 VYAFGIVMYELLA---------ECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAP-----QAL 661

Human   259 KELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQG 323
            |.|.:.|....|||||.|:..|       .|:||           .|..|...:|..|.|...|.
  Fly   662 KRLAEDCIKYTPKDRPLFRPLL-------NMLEN-----------MLRTLPKIHRSASEPNLTQS 708

Human   324 GTEMDGF 330
            ..:.|.|
  Fly   709 QLQNDEF 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RIPK3NP_006862.2 Protein Kinases, catalytic domain 27..280 CDD:473864 84/272 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..443
RHIM 448..468 CDD:463679
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455 450..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..518
RafNP_525047.1 RBD_RAF 142..212 CDD:340514
C1_Raf 221..269 CDD:410361
STKc_Raf 435..687 CDD:270964 86/283 (30%)
Blue background indicates that the domain is not in the aligned region.

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