DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RIPK3 and ZC581.7

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_491913.1	Gene:	ZC581.7 / 266838	WormBaseID:	WBGene00022634	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	296	Identity:	70/296 - (23%)
Similarity:	133/296 - (44%)	Gaps:	53/296 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    19 EELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA--------ISREVKAMASLDNEFVLRL 75
            ::::.::.:|.|.:|||:..:..|....:|||.::::.        :.:|.:.|...|:..:::.
Worm   118 KDVDFKKKLGSGAYGTVYLGRLTKNNTKIAVKKLDTEGNDEESLAEMMKEARVMQLYDHPNIVKF 182

Human    76 EGVIEKVNWDQDPKPALVTKFMENGSLSGLL---------QSQCPRPWPLLCRLLKEVVLGMFYL 131
            .|.|.     .|....||.:....||:...|         :::....:...|        |:.||
Worm   183 YGYIV-----DDIPYLLVLELCNGGSVEDKLVEKGAKLSTKTRIMYTYHAAC--------GIEYL 234

Human   132 HDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNR 196
            |.:.  .:|||:...|.|:..|: ||:||||:.  :..|.......:|..| .:||||::.|...
Worm   235 HKKK--CIHRDIAARNCLIHKEI-VKIADFGMC--RATSIYKVDLNKPTNT-RWLAPEVWDNGET 293

Human   197 KASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEG---- 257
            :.:|  |:::|.|.||...     |:|      |::..:......:.:..:||...|..:|
Worm   294 RDNT--DIFAFAITMWEFF-----EVP------YDSPYSEWKGYMVKQKTRAGYRLPTPKGMPWD 345

Human   258 LKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENN 293
            ::|:|:|||..:|..||:..|...|.:|.....|::
Worm   346 IEEIMKLCWHVDPNQRPTASELREKIEETMAKPESS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	67/278 (24%)
		PKc_like	27..280	CDD:304357	67/273 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
ZC581.7	NP_491913.1	SH2	9..97	CDD:301589
		Pkinase_Tyr	120..371	CDD:285015	67/282 (24%)
		PTKc	124..372	CDD:270623	68/279 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910