Protein Alignment RIPK3 and Y53F4B.1

DIOPT Version :9

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_497085.2
• Gene: Y53F4B.1 / 190206
• WormBaseID: WBGene00013149
• Length: 463
• Species: Caenorhabditis elegans
• Alignment Length: 472
• Identity: 104/472 - (22%)
• Similarity: 171/472 - (36%)
• Gaps: 158/472 - (33%)

Human    14 PLVSIE--ELENQEL-----------VGKGGFGTVFRAQHRKWGYDV----AVKIVNSKA---IS 58
            ||.|:|  :::..:|           :|.|.:..||...::  |:|.    ::|....|.   |.
 Worm     3 PLSSVELTDIKTDDLDIKWDNVQQFKLGDGSYADVFHVFYK--GHDAVLKRSIKEYTDKERENIR 65

Human    59 REVKAMASLDN-EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLL--QSQCPRPWPLLCRL 120
            ||.:.:|:|:| |.|:|:.|:.|.:     |...::.::....:||.|:  ..:|...:..| |:
 Worm    66 REARVVAALNNCENVVRIYGICETL-----PFRGMIMEYCAGPNLSELVFQLDECKVKFETL-RI 124

Human   121 LKEVVLGMFYLHD-------QNPVLLHRDLKPSNVLLD--------------------------- 151
            .|       :.||       .|....|.|:|..|||:.
 Worm   125 FK-------WCHDLTRTLCELNVTYYHGDVKAKNVLVKERPCCCVEGIYENVKIRNTTYSLCTIC 182

Human   152 -----PELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILM 211
                 ..|.:|:.|||:|......:...     |||..:.|||....:   .:..|:|||||.||
 Worm   183 NGVHLEHLSLKICDFGMSYEHKDKRLYN-----GGTREFSAPETIRGI---YTEKSEVYSFGHLM 239

Human   212 WAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLK-----ELMQLCWSSEPK 271
            ..::.|.    |||...   ||..|      |.|.....:...:.|.|     |.::.|.::..:
 Worm   240 LVLVIGG----PTEDDC---AVGQR------AFLKMYNNKKYDMSGCKSNSICETIEWCLNNTQE 291

Human   272 DRPSFQECLPK-------------TD----------EVF-------QMVENNMNAAVSTVKDFLS 306
            .||:|::.|.|             ||          |.|       :.:..:.....::....||
 Worm   292 SRPTFKQLLSKLNSRHTHYLSLRGTDTRRLEANNEREEFLDHYRIPRKISVHRRTTTTSTCISLS 356

Human   307 QLRSSNRRFSIPESGQ-GG---TEM------------------DGFRRT--IENQHSRNDVMVSE 347
            :...||:..|:..:.. ||   .:|                  |||.:|  :|||....|.....
 Worm   357 ETSGSNQDISVTSAAYLGGPIVNQMFIADTPLASPSASRKFRNDGFEKTNYVENQLYTGDETRKP 421

Human   348 WLNKLNLEEPPSSVPKK 364
            :|.. .:..|..||.:|
 Worm   422 FLTG-GISHPGYSVMRK 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	73/322 (23%)
		PKc_like	27..280	CDD:304357	72/306 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443		4/10 (40%)
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
Y53F4B.1	NP_497085.2	PKc	29..303	CDD:270622	73/309 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900