DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and K09B11.5

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_001040971.1	Gene:	K09B11.5 / 178307	WormBaseID:	WBGene00010712	Length:	589	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	115/451 - (25%)
Similarity:	177/451 - (39%)	Gaps:	105/451 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    21 LENQELVGKGGFGTVFRAQHRKWGY----DVAVKIVNSKA-------ISREVKAMASLDNEFVLR 74
            |||  ::|.|.||.|.:|::...|:    :||||.|...|       ...|.:.|.:|.::.|::
Worm   183 LEN--ILGNGAFGEVLKARYIPRGHTNGVEVAVKRVIGTAQREQMQEFCHEAQIMGTLKHDNVVK 245

Human    75 LEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLL 139
            |.|:.     ..:....||.:.:..|.|...|||....|...|.....::..||.:|..:.  ::
Worm   246 LYGIA-----SLEQPIMLVMELITGGDLKKYLQSTPSIPNRQLIAFALDIANGMRHLVIKK--VI 303

Human   140 HRDLKPSNVLLD-PELHVKLADFGLST------FQGGSQSGTGSGEPGGTLGYLAPELFVN--VN 195
            ||||...|.|:. |.|.||::||||:.      .:..|::.|         .:||||.|..  .|
Worm   304 HRDLAARNCLISRPTLQVKISDFGLAVQATEVIVKKLSKAPT---------RWLAPETFQKGIFN 359

Human   196 RKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP---ETPGLEG 257
            .|    :||:|||:::..:|. |....|..|..:.|  |.:.    :.|.|.  |   |....:.
Worm   360 EK----TDVWSFGVVLTEILT-RCAADPLAPRTLEE--CKKY----IIESPH--PHRIENKEPKE 411

Human   258 LKELMQLCWSSEPKDRPSFQEC--------------------LPKTDEVFQMVENNMNAAVSTVK 302
            |.||:::|.......|.:||..                    |.|::|..::......|.|:..|
Worm   412 LAELVEMCCDKNTMCRANFQNAKRRLKIVIDQYDHPDGHKLELKKSEEQKRLTIRRSTATVTRKK 476

Human   303 DFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKL------NLEEPPSSV 361
            .     |...|:.|:...|. ||:    |:.:.........:      ||      |||.|..
Worm   477 S-----RDGGRQASVERKGH-GTQ----RKVVSVLRKDKGAL------KLPSGIATNLERPSP-- 523

Human   362 PKKCPSLTKRSR-AQEEQVPQAWTAGTSSDSMAQPP--QTPETSTFRNQMPSPTSTGTPSP 419
                ||.|.:|. .:....|.......|...::|||  |.|.:....:|.|.|....||.|
Worm   524 ----PSHTAKSHTVKSPMTPPVSQPPVSQPPVSQPPVSQPPVSQPPVSQPPVPQHPMTPPP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	78/300 (26%)
		PKc_like	27..280	CDD:304357	76/295 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		19/68 (28%)
		RHIM	419..468	CDD:289491	1/1 (100%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
K09B11.5	NP_001040971.1	SH2	74..160	CDD:214585
		TyrKc	181..437	CDD:197581	79/284 (28%)
		PTKc	185..438	CDD:270623	77/283 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910