DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and sel-15

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_001366799.1	Gene:	sel-15 / 175225	WormBaseID:	WBGene00016030	Length:	847	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	98/325 - (30%)
Similarity:	156/325 - (48%)	Gaps:	37/325 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     9 SGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA---------ISREVKA 63
            |..|||. :.:.|:|.||.:|.|.||.|::..:|  |..||||...:.|         :.|||..
Worm   503 SALPAPFHLCLAEIEFQESIGSGSFGKVYKGTYR--GKLVAVKRYRAMAFGCKSETDMLCREVSI 565

Human    64 MASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLL-CRLLKEVVLG 127
            ::.|.:..|:...|    .:.|...:.|::|:|:|||||..||..:.....|.. .|:..:|..|
Worm   566 LSRLAHPNVVAFVG----TSLDDPSQFAIITEFVENGSLFRLLHEEKRVMDPAFRLRISLDVARG 626

Human   128 MFYLHDQ--NPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPEL 190
            |.|||:.  .|| :||||...|:|:..:....:||||.|.|....:....:.:| |.|.::|||:
Worm   627 MRYLHESAAKPV-IHRDLNSHNILIHADGRSVVADFGESRFVCQREDENLTKQP-GNLRWMAPEV 689

Human   191 FVNVNRKASTASDVYSFGILMWAVLAGREVELP---TEPSLVYEAVCNRQNRPSLAELPQAGPET 252
            | :.:.|.....||:||.:::|.:   ...|||   .:|:.....:..::.||:|...|.|  :.
Worm   690 F-SQSGKYDRKVDVFSFALVIWEI---HTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTA--QF 748

Human   253 PGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSI 317
            |.  .:..|:...|..|...||.|.|.:...:...:....:::|. |||    |||.|...:.|:
Worm   749 PA--HILSLIPQAWHPESSSRPDFVEIVALLEPHVESTHTDISAP-STV----SQLTSQWEQLSV 806

Human 318 317
Worm 807 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	84/272 (31%)
		PKc_like	27..280	CDD:304357	81/267 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
sel-15	NP_001366799.1	ANKYR	3..217	CDD:223738
		ANK repeat	115..147	CDD:293786
		PHA03095	128..>388	CDD:222980
		ANK repeat	153..180	CDD:293786
		ANK repeat	182..213	CDD:293786
		ANK repeat	215..246	CDD:293786
		ANK repeat	285..318	CDD:293786
		ANK repeat	320..353	CDD:293786
		ANKYR	<323..458	CDD:223738
		ANK repeat	355..380	CDD:293786
		PKc_TNNI3K	522..780	CDD:270966	81/273 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910