Protein Alignment RIPK3 and let-23

DIOPT Version :9

• Sequence 1: NP_006862.2
• Gene: RIPK3 / 11035
• HGNCID: 10021
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_001300607.1
• Gene: let-23 / 174462
• WormBaseID: WBGene00002299
• Length: 1335
• Species: Caenorhabditis elegans
• Alignment Length: 468
• Identity: 115/468 - (24%)
• Similarity: 189/468 - (40%)
• Gaps: 126/468 - (26%)

Human    15 LVSIEELENQ--ELVGKGGFGTVF-------RAQHRKWGYDVAVKIVNSKAISREVKAMASLDNE 70
            |:...||:.:  :.:|.|.|||||       ||::.|  ..||:|:..:.. |:..:.:....|.
 Worm   889 LIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVK--IPVAIKVFQTDQ-SQTDEMLEEATNM 950

Human    71 FVLRLEGVIEKVNW-DQDPKPALVTKFMENGSLSGLL----QSQCPRPWPLLCRLLKEVVLGMFY 130
            |.||.:.:::.:.: ..|....:||.:...|:|...|    ::...|...|.|   .::..||.|
 Worm   951 FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYC---YQIASGMQY 1012

Human   131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLS----------TFQGGSQSGTGSGEPGGTLGY 185
            |..|.  ::||||...|||:....||::.|||||          |.:.|..:          :.:
 Worm  1013 LEKQR--VVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVA----------IKW 1065

Human   186 LAPELFVNVNRKAST-ASDVYSFGILMWAVLAGREVELPTEPSLVYEAVC-----------NRQN 238
            ||.|:|   ::...| ||||::||:..|        |:.|.....|:.:.           ||.:
 Worm  1066 LAIEIF---SKHCYTHASDVWAFGVTCW--------EIITFGQSPYQGMSTDSIHNFLKDGNRLS 1119

Human   239 RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQ---ECLPKTDEVFQMVENNMNAAVST 300
            :|     |....:.     .:||:: ||.::||.||.|:   |...:..:|.|:...|.|..  :
 Worm  1120 QP-----PNCSQDL-----YQELLR-CWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKI--S 1171

Human   301 VKDFLSQLRSSNRRF-----------------SIPESGQGGTEMDGFRRTIENQHSRNDVMVSEW 348
            ..|..::.|....|.                 |:|......|.|..|  ||.:    .|:|
 Worm  1172 ESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATF--TIPH----GDLM---- 1226

Human   349 LNKLNLEEPPSSVPKKCPSLTKRSRAQEE---------QVPQA---WTAGTSSDSMAQPPQTPET 401
                |..:..:|...|.......|.|||:         :|.|:   :||.|:.|  .|...:|..
 Worm  1227 ----NRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNED--GQTELSPSN 1285

Human   402 STFRNQMPSPTST 414
            ..:.||..:|:|:
 Worm  1286 GDYYNQPNTPSSS 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	77/296 (26%)
		PKc_like	27..280	CDD:304357	77/289 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..443		18/72 (25%)
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..518
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:279382
		Furin-like	229..378	CDD:279142
		FU	274..>308	CDD:238021
		Recep_L_domain	396..503	CDD:279382
		GF_recep_IV	531..652	CDD:291509
		FU	532..580	CDD:238021
		FU	578..625	CDD:214589
		FU	759..806	CDD:214589
		PKc_like	885..1164	CDD:304357	82/314 (26%)
		TyrKc	898..1153	CDD:197581	77/294 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910