DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RIPK3 and lrk-1

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_492839.4	Gene:	lrk-1 / 172995	WormBaseID:	WBGene00003068	Length:	2393	Species:	Caenorhabditis elegans

Alignment Length:	402	Identity:	104/402 - (25%)
Similarity:	158/402 - (39%)	Gaps:	119/402 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    19 EELENQELVGKGGFGTVFRAQHR------------------------------------KWGYDV 47
            ::|:...::|:|.||.||||..|                                    ||..|.
Worm  1692 DQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDS 1756

Human    48 AVKIVNSKAISR-EVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQC 110
            ......:...|| |:..::.:.:..|:.|.||.        ..| :||.:....|:|:.||.|..
Worm  1757 MEFACRAYCTSRQELSLLSRMKHPNVIGLVGVC--------TFPLSLVVELAPLGALNQLLGSHR 1813

Human   111 PRPWPLLCRLLKE----VVLGMFYLHDQNPVLLHRDLKPSNVL-------LDPELHV--KLADFG 162
            .....|...::||    |...:.|||..:  :::||||..|||       ..|:..|  ||.|:|
Worm  1814 KAGTKLSLGVIKESAVQVARALEYLHSAH--IIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYG 1876

Human   163 LSTFQGGSQSGTGSGEPGGTLGYLAPELF-VNVNRKASTASDVYSFGILMWAVLAGREVELPTEP 226
            :|  :....||...|. |||.|::|||:. .|...:.:...|.:|||:.::.:|.   ::.|.|.
Worm  1877 IS--RSVLPSGGAKGF-GGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT---LKFPFES 1935

Human   227 SLVYEAVCNRQ---NRPSLAE----LPQAGPETPGLEGLKELMQLCWSSEPKDRPS--------- 275
            .   |.|..|.   .||.|..    ||     ||.|    :|:..|||:.|:.|||
Worm  1936 E---EHVKERMLDGARPVLLPHELLLP-----TPML----DLLVHCWSAHPESRPSSSQLVGFCA 1988

Human   276 ------------FQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMD 328
                        ..|.||.|    |::...:...:....||.:||..|.|...:    .|.|:.
Worm  1989 APEFTHLLDVCELGEALPPT----QLMAVGITDEIDDPDDFEAQLWLSGREMVV----MGCTQY- 2044

Human   329 GF--RRTIENQH 338
            ||  :::||..|
Worm  2045 GFVDQKSIELPH 2056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	86/337 (26%)
		PKc_like	27..280	CDD:304357	86/332 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
lrk-1	NP_492839.4	Ank_2	29..121	CDD:289560
		ANK	51..218	CDD:238125
		ANK repeat	56..88	CDD:293786
		ANK repeat	90..121	CDD:293786
		ANK	192..337	CDD:238125
		ANK repeat	197..228	CDD:293786
		Ank_2	202..286	CDD:289560
		ANK repeat	230..262	CDD:293786
		Ank_2	269..390	CDD:289560
		ANK	312..456	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:289560
		ANK repeat	398..432	CDD:293786
		LRR_RI	<512..>639	CDD:238064
		leucine-rich repeat	534..555	CDD:275380
		LRR_8	554..615	CDD:290566
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		LRR_8	718..776	CDD:290566
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR_8	857..915	CDD:290566
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop_NTPase	977..1160	CDD:304359
		COR	<1239..>1336	CDD:292713
		S_TKc	1698..1983	CDD:214567	85/312 (27%)
		PKc_like	1699..1990	CDD:304357	85/318 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900