DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and mom-4

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_492620.1	Gene:	mom-4 / 172842	WormBaseID:	WBGene00003396	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	126/487 - (25%)
Similarity:	194/487 - (39%)	Gaps:	128/487 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    16 VSIEELE-------NQELVGKGGFGTVFRAQHRKWGYD----VAVKI---VNSKAISREVKAMAS 66
            :.|.|::       |...:|||.:|.|.:.::||...|    .|:|.   ::...:.||.|.|..
Worm    39 IDIPEIQAQCIDNLNSHYLGKGTYGLVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVMWD 103

Human    67 LDNE-FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMF- 129
            |.|. .::::.|:.:.....|    .:|.::|:.||::.||..:..     :...:..|...||
Worm   104 LRNHPNIIKIYGLYKSPRNGQ----GVVMEYMDCGSMADLLYDRTH-----INYTIDHVASWMFQ 159

Human   130 ------YLHDQNPVLLHRDLKPSNVLL-DPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLA 187
                  :.|..:.|  |||||..|:|| |....:||.|||  ||....||.|.:   .||...:|
Worm   160 LSSAVDFFHSNSQV--HRDLKLQNMLLSDRYRTMKLCDFG--TFTSMHQSMTSN---RGTPITMA 217

Human   188 PELF--VNVNRKASTASDVYSFGILMWAVLA-----GREVELPTEPSLVYEAVCNRQNRPSLAEL 245
            ||:|  ...|.|    ||:||.||:||.::|     .|::.:   |.|:|. |.....||.  ||
Worm   218 PEVFRCEQYNMK----SDIYSIGIIMWQIIARNHPYRRDLSV---PGLLYN-VATANLRPQ--EL 272

Human   246 PQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM-NAAVSTVKDFLSQLR 309
             :..|.      |.|..:.||:.....||:..||:    |.|.::::.. |.:|.     ||. .
Worm   273 -ECNPI------LSEFYKKCWNDNADIRPTSSECV----EYFTLLKDEYPNGSVP-----LSD-S 320

Human   310 SSNRRFSIP------------ESGQG-GTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSV 361
            |:|.....|            .||.| |              |.|....:..|  ||.::|...
Worm   321 STNGPAETPPPHAHRPTMLGTSSGSGIG--------------SNNRTPTASKL--LNPQQPGQG- 368

Human   362 PKKCPSLTKRSRAQ----EEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPS----PTSTGTPS 418
                   .:|:|::    :..:|.....|.:..|.. |....|...||::..|    |.....|.
Worm   369 -------HRRNRSETFVVQPDLPYPTVPGEAGASRI-PKSQSEAKNFRDRAKSEQRQPHRDARPP 425

Human   419 PGP----RGNQGAERQG--MNWSCRTPEPNPV 444
            | |    |.:...|:..  || .|...|..|:
Worm   426 P-PFEHRRDSNDEEKHAVFMN-ICSNEETRPI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	83/287 (29%)
		PKc_like	27..280	CDD:304357	82/275 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		21/101 (21%)
		RHIM	419..468	CDD:289491	9/32 (28%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
mom-4	NP_492620.1	PKc_like	57..303	CDD:304357	84/282 (30%)
mom-4	NP_492620.1	S_TKc	57..301	CDD:214567	83/280 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900