DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIPK3 and ripk3

DIOPT Version :9

Sequence 1:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens
Sequence 2:	XP_001343827.1	Gene:	ripk3 / 100004555	ZFINID:	ZDB-GENE-071115-4	Length:	433	Species:	Danio rerio

Alignment Length:	479	Identity:	151/479 - (31%)
Similarity:	211/479 - (44%)	Gaps:	85/479 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    27 VGKGGFGTVFRAQHRKWGYDVAVKIVNSK-----AISREVKAMASLDNEFVLRLEGVIE-KVNWD 85
            ||.||||.:|||:|..||.|||||:::.|     :..||.:.|....|..|:|:.||.| ::...
Zfish    24 VGSGGFGQIFRARHTLWGTDVAVKLLHYKEGSASSAQREAELMFDAGNSNVVRVLGVYEGRLGDP 88

Human    86 QDP-KPALVTKFMENGSLSGLLQS-QCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNV 148
            |.| :..||.:|:..|||..|||. ..|.|..|..|:..:|.|||.:||...|.:||.|||||||
Zfish    89 QRPLQCGLVLEFLARGSLEDLLQRLAAPPPCALALRMALQVSLGMNFLHQLTPPILHLDLKPSNV 153

Human   149 LLDPELHVKLADFGLSTFQGG--SQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILM 211
            ||...|..|:.|||||.....  ..:|....:.||||.|:.||...:.:.|.|.|.||||:|||:
Zfish   154 LLSDSLDAKITDFGLSRVAENVCKYTGVNDEDEGGTLSYMPPEALQSSSYKPSKAFDVYSYGILL 218

Human   212 WAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSF 276
            |:::.|:|.....:.|||...: ...:||.||.:..:  ||.||:.|.:||..||..||..||||
Zfish   219 WSIITGKEPYSGVQSSLVRFRI-PLGDRPDLASVDCS--ETEGLDELLKLMMQCWDQEPHRRPSF 280

Human   277 QECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRN 341
            .:|:.....::.|....:|   ..|.|.|.||:..                       |...|..
Zfish   281 LDCVHAITAIYTMHARRLN---DDVHDVLEQLQDD-----------------------EICSSLR 319

Human   342 DVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRN 406
            .|.:|   .|.:.|..|..:  .|.:    ..|.:::...|:|.....:  ..|...|.....|.
Zfish   320 SVQIS---RKPHREVDPQDL--SCVT----GPAPQQETAAAYTETVQKE--CSPRAAPPVGAIRK 373

Human   407 QMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQT 471
                 |...|.:|..:                           |::.|..|||:|:||.:.:.|.
Zfish   374 -----TQRQTSNPAVQ---------------------------VSMSNVFGVQIGNNNSMNITQK 406

Human   472 TALPTWGLAPSGKGRGLQHP--PP 493
            .. .....|||.......||  ||
Zfish   407 PR-QRHRTAPSAVNTHSSHPQNPP 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	110/262 (42%)
		PKc_like	27..280	CDD:304357	110/262 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443		12/87 (14%)
		RHIM	419..468	CDD:289491	9/48 (19%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518		7/20 (35%)
ripk3	XP_001343827.1	TyrKc	20..287	CDD:197581	111/265 (42%)
ripk3	XP_001343827.1	PKc_like	24..285	CDD:304357	111/263 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31410
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251670at7742
OrthoFinder	1	1.000	-	-		FOG0007085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7541
SonicParanoid	1	1.000	-	-		X6895
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	10	10.550