Protein Alignment TDRKH and tdrkh

DIOPT Version :10

• Sequence 1: NP_006853.2
• Gene: TDRKH / 11022
• HGNCID: 11713
• Length: 561
• Species: Homo sapiens
• Sequence 2: XP_073773714.1
• Gene: tdrkh / 541541
• ZFINID: ZDB-GENE-050327-81
• Length: 885
• Species: Danio rerio
• Alignment Length: 562
• Identity: 238/562 - (42%)
• Similarity: 337/562 - (59%)
• Gaps: 50/562 - (8%)

Human     8 WTSLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVPQEAVKLIIGRQG 72
            |.|||:.:|:||..||...|||.|::||..|.|.|:     .:...|..:.||.:..:.|...|.
Zfish    41 WKSLSSGKKVALAAGISVGATVGYLIYRHIRNSTEQ-----CQSKEESRISVPLDVYRSIARYQS 100

Human    73 ANIKQLRKQTGARIDV--DTEDVGDERVLLISGFPVQVCKAKAAIHQILTENTPVSEQLSVPQRS 135
            |.:..:.:::||:|:|  :||:..... .||.|.|.|:..|:.|:.::.|:...:::.:.|||.:
Zfish   101 AFLDIVNQKSGAQINVLPNTEEQNMVN-FLIQGSPEQILIAQCALEKLATDCEVITDVIDVPQTA 164

Human   136 VGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQKEVAAAKHLILEKVSEDEEL 200
            .||||||||||::.|.:.||||:.|.|:...||..:..|.|:||:||:.:||.:|:|||.|:|.:
Zfish   165 FGRIIGRGGETLKFINRVSGAKVNCSKDRGRTLEENGKITITGTRKEIQSAKEMIMEKVIENETV 229

Human   201 RKRIAHSAETRVPRKQPISVRRE-DMTEPGGAGEPALWKNTSSSMEPTAPLVTPPPKGGGDMAVV 264
            ||||:.::..|..||.|.:...| ::.:|.|...|.|.......:..|.         .|.:...
Zfish   230 RKRISQASALRQRRKPPETQGPENELLKPNGKDLPTLVNELKQELPVTV---------NGYVDST 285

Human   265 VSKEGSWEKPSDDSFQKSEAQAIPEMPMFEIPSPDFSFHADEYLEVYVSASEHPNHFWIQIVGSR 329
            .:.|.|..  |:|....|....: |:..|||||||.||..||:|||||||||:|.||||||:|.|
Zfish   286 DTAENSLR--SEDEEILSPVSPL-EISKFEIPSPDLSFQPDEHLEVYVSASENPQHFWIQILGVR 347

Human   330 SLQLDKLVNEMTQHYENSVPED---LTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDF 391
            |||||||..||::.|.....::   .|:.||||||||...:|:|.||||||.:.:|.:|||:|||
Zfish   348 SLQLDKLTAEMSRFYNGDSSQEHRVETIIVGDIVAAPYRDHGTWNRARVLGIVGSGLVDLYYVDF 412

Human   392 GDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEFDRLTHCADWKPLVAKIS 456
            ||||:.|.:.||::|||||||||||||||||.:.|.|:.|.|.|||:|:|:|.||:||||:||:.
Zfish   413 GDNGELPREHLRSMRSDFLSLPFQAIECSLAGVRPEGEVWTEAALDDFERMTFCAEWKPLLAKLY 477

Human   457 SYVQTGISTWPKIYLYDTSNGKKLDIGLELVHKGYAIE-------LPEDIEENRAVPDMLKDMAT 514
            ||..:.||:||.:.|||.|.||.:|:|.||:..|:|:.       |..|.:|:|::..||.|| |
Zfish   478 SYSHSEISSWPSVKLYDNSQGKAVDLGKELIRLGHAVSCEDEGNGLRGDWDESRSLQKMLDDM-T 541

Human   515 ETDASLSTLLTETKKSSGEITHTLSCLSLSEAASMSGDDNLE 556
            ...:.||                :||:|||  .|...:|.||
Zfish   542 GATSELS----------------MSCISLS--GSPWVNDQLE 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDRKH	NP_006853.2	KH-I_TDRKH_rpt1	49..119	CDD:411856	19/71 (27%)
		KH-I_TDRKH_rpt2	124..205	CDD:411857	39/80 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..262		7/43 (16%)
		Tudor_TDRD2	328..420	CDD:410483	55/94 (59%)
tdrkh	XP_073773714.1	None