DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATF7 and kay

DIOPT Version :9

Sequence 1:	NP_001353484.1	Gene:	ATF7 / 11016	HGNCID:	792	Length:	494	Species:	Homo sapiens
Sequence 2:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	89/397 - (22%)
Similarity:	146/397 - (36%)	Gaps:	108/397 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   179 TLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIP 243
            ||.:|    |..|.:.|.:....|.|     |::.||..|.......:|.|:..|..| :...||
  Fly   246 TLTTP----TLTPTTTRNIEDTLGHL-----LSDTQTDRVAGCAGFAVPKVLPNAIDV-LGMGIP 300

Human   244 -GIPGPPVNSS-------GSISPSGHPIPSEAKMRLKATLTHQVS----------------SING 284
             |:...|:..:       ||.|...:...::.:|..:...|...|                |:||
  Fly   301 TGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNG 365

Human   285 G-----CGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRR-RRTVDEDPD 343
            |     ..::...:|:..:|....|.           |....:||:   ..|||| .|:.:..|:
  Fly   366 GGVNNFSNVLAAVSSSRGSASVGSSN-----------ANTSNTPAR---RGGGRRPNRSTNMTPE 416

Human   344 ERRQRFL--ERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAH 406
            |.::|.:  |||:.||:|||::|....:.|.::.|:|..:...:..|:.:|.|...||:.||..|
  Fly   417 EEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATH 481

Human   407 K--------------DC-----PVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNG-- 450
            :              .|     |...|...:.|...|...:.....|....|....||..|.|
  Fly   482 RATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRS 546

Human   451 ---LSVRSAAEAVATSVLTQMASQRTE-------------------LSMPIQS---HV----IMT 486
               |.::.||.  ..|:|..:..:..:                   :::|..|   ||    |:|
  Fly   547 NSPLDLKPAAN--IDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTMPHVHLSTILT 609

Human   487 PQSQSAG 493
            |...|:|
  Fly   610 PTGASSG 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATF7	NP_001353484.1	C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		bZIP_ATF2	345..405	CDD:269835	20/61 (33%)
		coiled coil	345..405	CDD:269835	20/61 (33%)
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	20/60 (33%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	20/58 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840