DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATF7 and CrebB

DIOPT Version :9

Sequence 1:	NP_001353484.1	Gene:	ATF7 / 11016	HGNCID:	792	Length:	494	Species:	Homo sapiens
Sequence 2:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	319	Identity:	65/319 - (20%)
Similarity:	110/319 - (34%)	Gaps:	77/319 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   122 PVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSV 186
            |.:...:|..:.|..|.......:......||.:|....|..|.......|.........:|:.|
  Fly    48 PQQQQQNPQSTTAGGPTGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVQSVIQANPSGV 112

Human   187 ITQAPPSNRQMGSPTGSLPL--VMHLA---NGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIP 246
            |..|..:.:|..:...:..:  |:::|   |...:...||..||:.:.|.        |..|...
  Fly   113 IQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIP--------PTFPCKI 169

Human   247 GPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQIL--IQ 309
            .|..|:.       ||..|:..:....:..|:                :.:|.||..::|.  |.
  Fly   170 KPEPNTQ-------HPEDSDESLSDDDSQHHR----------------SELTRRPSYNKIFTEIS 211

Human   310 HPDAPSPAQP-------------------------QVSP--------AQPTPSTGGRRRRTVDED 341
            .||....:.|                         |:.|        :..|.::|      :.||
  Fly   212 GPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSG------IAED 270

Human   342 PDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLK 400
            ...:|:..|::||.||..||:|:|.::..||.:...|.:||..|..|:..|:....|.|
  Fly   271 QTRKREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATF7	NP_001353484.1	C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		bZIP_ATF2	345..405	CDD:269835	20/56 (36%)
		coiled coil	345..405	CDD:269835	20/56 (36%)
CrebB	NP_001334685.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940