DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHAD and Toll-7

DIOPT Version :9

Sequence 1:	XP_011522516.1	Gene:	CHAD / 1101	HGNCID:	1909	Length:	440	Species:	Homo sapiens
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	264	Identity:	82/264 - (31%)
Similarity:	122/264 - (46%)	Gaps:	24/264 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   137 LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIR----------EVAAGAFRGLKQLIYLYLSHND 191
            |:|..||...|.:.....:.||..|:|...:||          ...||:.....:|..|..|||:
  Fly   194 LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNE 258

Human   192 IR-VLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLR 255
            :| :..:.....|..|.:|.|.:|.::||....|:.|.:|.|:.|:||.:..|..|.|.|:|:||
  Fly   259 LRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELR 323

Human   256 WLYLSENALSSLQPGALDDVENLAKFHVDRNQLSS-----YPSAALSKLRVVEELKLSHNPLKSI 315
            .::|.:|.|..|..|....:|.|....:..|||:|     ...|.|.:|.|   |.|:||.|..|
  Fly   324 EIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIV---LNLAHNALTRI 385

Human   316 PDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETLA 377
            ....|:.. .:|:.|.|.|.::....|.|||.:..|..::|..|||:.|.... |:.   |..|.
  Fly   386 DYRTFKEL-YFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKL-FNGLYVLSKLT 448

Human   378 LTNN 381
            |.||
  Fly   449 LNNN 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHAD	XP_011522516.1	LRRNT	104..130	CDD:279764
		leucine-rich repeat	134..157	CDD:275380	5/19 (26%)
		LRR_8	156..216	CDD:290566	19/70 (27%)
		leucine-rich repeat	158..181	CDD:275380	7/32 (22%)
		LRR_RI	<171..363	CDD:238064	64/197 (32%)
		leucine-rich repeat	182..205	CDD:275380	7/23 (30%)
		LRR_8	204..264	CDD:290566	22/59 (37%)
		leucine-rich repeat	206..229	CDD:275380	8/22 (36%)
		leucine-rich repeat	230..253	CDD:275380	9/22 (41%)
		leucine-rich repeat	254..277	CDD:275380	7/22 (32%)
		leucine-rich repeat	278..301	CDD:275380	8/27 (30%)
		LRR_8	302..361	CDD:290566	18/58 (31%)
		leucine-rich repeat	302..325	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		leucine-rich repeat	351..373	CDD:275380	7/24 (29%)
		LRRCT	381..428	CDD:214507	1/1 (100%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	3/6 (50%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	18/64 (28%)
		leucine-rich repeat	191..214	CDD:275380	5/19 (26%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	69/211 (33%)
		LRR_8	247..308	CDD:290566	20/60 (33%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		LRR_8	297..356	CDD:290566	20/58 (34%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	20/64 (31%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	9/26 (35%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	12/35 (34%)
		leucine-rich repeat	420..443	CDD:275380	7/23 (30%)
		leucine-rich repeat	444..467	CDD:275380	5/9 (56%)
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010