DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC27A3 and Fatp2

DIOPT Version :9

Sequence 1:	NP_077306.3	Gene:	SLC27A3 / 11000	HGNCID:	10997	Length:	683	Species:	Homo sapiens
Sequence 2:	NP_995925.2	Gene:	Fatp2 / 37657	FlyBaseID:	FBgn0265187	Length:	714	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	214/538 - (39%)
Similarity:	303/538 - (56%)	Gaps:	35/538 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   167 GATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEF---LESL 228
            |..|.|||....||:..|.||:|.|:.|..:.|.||...|.|.:......||:....|   :..:
  Fly   189 GDVVGLLLENRAEFVATWLGLSKIGVITPLINTNLRGASLQHSITVGQCTALIYGASFRSAVMDI 253

Human   229 EPDLPALRAMGLHLW--------AAGPGTHPAGISDL--LAEVSAEVDGPVPGYLSSPQSITDTC 283
            ..||||  .:||:.:        .|..|........|  |.|.:|: |....|  :|.....|..
  Fly   254 AKDLPA--HVGLYQFNDESNQEVVASEGLSQGLAQQLNGLLETAAK-DKVAAG--ASRADHHDKL 313

Human   284 LYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVH------QEDVIYLALPLYHMSGSLLGIVGC 342
            :||:|||||||||||.|:|.:.     |:...|:|      .:||.|..|||||.:|.::.:...
  Fly   314 VYIYTSGTTGLPKAAVITHSRY-----FFIAAGIHYTLGFKDQDVFYTPLPLYHTAGGVMSMGQA 373

Human   343 MGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPD 407
            :..|:|||::.||||..::.||.:.:.||.|||||:.||::..|.:..:|.|:||:..|:||||.
  Fly   374 LLFGSTVVIRKKFSASGYFSDCARFQCTVGQYIGEMARYILATPSAPHDRNHQVRMVFGNGLRPQ 438

Human   408 TWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRD 472
            .|.:||.|||..:|.|.||.||||...:|.....||:|..|.:...|:|.|:|:.|..||||:|:
  Fly   439 IWPQFVERFGIRKVGEFYGATEGNANIMNNDSTVGAIGFISRILPQIYPISIIKADPHTGEPLRN 503

Human   473 PQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDD 534
            .||.|......|||:.|..:.:.:|   ||||. ..:.:..|::.|||..||:.|.:|||||.|:
  Fly   504 SQGLCERCEADEPGVFVGKIVRGNPCREFLGYV-DQKASSKKVVHDVFSKGDMAFISGDLLVADE 567

Human   535 QGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHA 599
            :|:|.|.||||||||||||||:|:||......|...::|.||||::|..|||||||| :..|...
  Fly   568 RGYLYFKDRTGDTFRWKGENVSTSEVEAQLSNLAGYKDVIVYGVSIPNTEGRAGMAA-IYDPTRE 631

Human   600 LDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGA 664
            :::.||...::::||.||||:|||....:..|.|||.:||.:..:||:|..:.|.|:.. |..|.
  Fly   632 VNVSQLGVELAKSLPNYARPQFLRFLRKIDLTGTFKLRKVELQQQGFNPEIIDDELFYA-QPDGV 695

Human   665 YLPLTTARYSALLAGNLR 682
            |.|||.:.|..::...||
  Fly   696 YAPLTPSVYERIVRNELR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC27A3	NP_077306.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..145
SLC27A3	NP_077306.3	hsFATP2a_ACSVL_like	163..673	CDD:213304	211/527 (40%)
Fatp2	NP_995925.2	PRK08279	115..714	CDD:236217	214/538 (40%)
Fatp2	NP_995925.2	AFD_class_I	163..680	CDD:302604	202/502 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298283at2759
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950