Protein Alignment COPS5 and CSN6

DIOPT Version :10

• Sequence 1: NP_006828.2
• Gene: COPS5 / 10987
• HGNCID: 2240
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_524451.1
• Gene: CSN6 / 42661
• FlyBaseID: FBgn0028837
• Length: 341
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 72/353 - (20%)
• Similarity: 112/353 - (31%)
• Gaps: 151/353 - (42%)

Human     2 AASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAA--------------------KPWT 46
            ||:||.||               :|:....:.:.|..|:||                    :.||
  Fly    20 AAAGSSMA---------------VDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWT 69

Human    47 KDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVE--GTETRVNA 109
            :                   ..|:.|...:|.|.::||..|..:.||:||.|..:  |.||.:|.
  Fly    70 R-------------------FRAQHGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINK 115

Human   110 QAAAYEYMAAYIENAKQVGRLENAIGWYHS--HPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDP 172
                 :|.....:..|||....:.||||.:  :|      :..|:..|
  Fly   116 -----DYYNKKEQQYKQVFSDLDFIGWYTTGDNP------TADDIKIQ----------------- 152

Human   173 TRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKL 237
             |.|:|  :|               |.|...|..||::..|                  .|..||
  Fly   153 -RQIAA--IN---------------ECPIMLQLNPLSRSVD------------------HLPLKL 181

Human   238 LELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAK 302
            .|.|                 .|...|:...|...|          ::.|..|..:|...|.:|:
  Fly   182 FESL-----------------IDLVDGEATMLFVPL----------TYTLATEEAERIGVDHVAR 219

Human   303 AT-RDSCKTTIEAIHGLMSQVIKDKLFN 329
            .| .:|.:.::.|.| |::|....|:.|
  Fly   220 MTSNESGEKSVVAEH-LVAQDSAIKMLN 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COPS5	NP_006828.2	MPN_RPN11_CSN5	44..314	CDD:163700	55/274 (20%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	138..151		1/14 (7%)
CSN6	NP_524451.1	MPN_CSN6	52..335	CDD:163694	61/306 (20%)