Protein Alignment COPS5 and Rpn11

DIOPT Version :10

• Sequence 1: NP_006828.2
• Gene: COPS5 / 10987
• HGNCID: 2240
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_608905.1
• Gene: Rpn11 / 33738
• FlyBaseID: FBgn0028694
• Length: 308
• Species: Drosophila melanogaster
• Alignment Length: 261
• Identity: 92/261 - (35%)
• Similarity: 142/261 - (54%)
• Gaps: 38/261 - (14%)

Human    57 ISALALLKMVMHARSGGNLEVMGLMLGK-VDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY 120
            ||:||||||:.|.|:|..:||||||||: ||..|:.::|.||:|..|  |.|:.:|....:.|..
  Fly    31 ISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVQVIDVFAMPQTG--TGVSVEAVDPVFQAKM 93

Human   121 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGA 185
            ::..||.||.|..:||||||||:||||||:|::||...:...|..||||:||.:::. |||.:.|
  Fly    94 LDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVK-GKVVIDA 157

Human   186 FRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHC------KQYYALEVSYFKSSLDRKLLELLWNK 244
            ||..........:.|.: .|..|..::...|..      :.||::.::|.|:.|::|:|..|..|
  Fly   158 FRLINPNMLVLGQEPRQ-TTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKK 221

Human   245 YWVNTLSSSSLLTNADY---------TTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL 300
            .|.:.      ||.:||         |..::.||::...:|            ||..::.:.::|
  Fly   222 SWKDG------LTLSDYNEHCSINEDTVAEMLDLAKNYNKS------------LEDEEKMTPEQL 268

Human   301 A 301
            |
  Fly   269 A 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COPS5	NP_006828.2	MPN_RPN11_CSN5	44..314	CDD:163700	92/261 (35%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	138..151		11/12 (92%)
Rpn11	NP_608905.1	MPN_RPN11_CSN5	19..284	CDD:163700	92/261 (35%)