DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPRE2 and CG15306

DIOPT Version :9

Sequence 1:	NP_055083.1	Gene:	MAPRE2 / 10982	HGNCID:	6891	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001259403.1	Gene:	CG15306 / 31961	FlyBaseID:	FBgn0030191	Length:	357	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	84/301 - (27%)
Similarity:	132/301 - (43%)	Gaps:	50/301 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    46 VNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKL 110
            |.|...|:.|  .||.||:.|.|:.:..|...:||||:|||||..|.||:|..|:||:|||.:..
  Fly     9 VTVTHNSLVQ--WSRGDILDWFNETLQCNLINIEQLCTGAAYCNLMHMLYPKLINLKRVKFFSNQ 71

Human   111 EHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKE---YDPVEA 172
            |:||::|||.||.:|.::||.....|..|:||...:|..|..||:.|::.|:...:   ||.:.|
  Fly    72 EYEYVNNFKELQKAFNKVNVSLPAEVNDLIKGHRVENFKFAVWFRHFFNVNHTKDKCAGYDALVA 136

Human   173 RQ------GQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSG 231
            |.      |...:...|.    |.|.|.     ..||...|.:......::......|.:...|.
  Fly   137 RDHQNIGIGSSKLTTKDR----FRLVKV-----KTTAIRGKVATCQATINSSLCTGKANQDEDSQ 192

Human   232 SASKSDKDLETQVIQLNEQVHSLKLALEGVE------KERDFYF----GKLREIELLCQEHGQEN 286
            ...|.|:|...|..|..:.        .|::      :::|..:    ||..:.: .|::.|.:.
  Fly   193 HTDKKDEDSRDQGSQYEDS--------PGMDSQYKDCRDQDSQYEDSHGKDSQYK-DCRDQGSQY 248

Human   287 DDLVQRLMDILYASEEHEGHTEEPEAEEQAHEQQPPQQEEY 327
            :|  ...||..|         |:...::..:|..|....:|
  Fly   249 ED--SHGMDSQY---------EDSRDQDSQYEDSPGMDSQY 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPRE2	NP_055083.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		BIM1	59..313	CDD:227542	77/272 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..240		14/74 (19%)
		DCTN1-binding	187..327		26/149 (17%)
		APC-binding	259..302		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..327		3/27 (11%)
CG15306	NP_001259403.1	CH	20..103	CDD:278723	39/82 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810