Protein Alignment RAB32 and Rab35

DIOPT Version :10

• Sequence 1: NP_006825.1
• Gene: RAB32 / 10981
• HGNCID: 9772
• Length: 225
• Species: Homo sapiens
• Sequence 2: NP_608373.1
• Gene: Rab35 / 33014
• FlyBaseID: FBgn0031090
• Length: 201
• Species: Drosophila melanogaster
• Alignment Length: 212
• Identity: 72/212 - (33%)
• Similarity: 115/212 - (54%)
• Gaps: 26/212 - (12%)

Human    23 EHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQER 87
            :||||:|:||:.||||:|::.|:....||..|..||||||.::.::.:... |:||:||.|||||
  Fly     6 DHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMR-VKLQIWDTAGQER 69

Human    88 FGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQ----- 147
            |..:|..||:...|..||:|::...:|..|.:|..::.:     |...:..||:.||.|.
  Fly    70 FRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQN-----NCDVVKKVLVGNKNDDPDRKV 129

Human   148 --NKDSSQSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKILVNH--QSFPNEENDVDK 208
              .:|:.:...|:|        ...||||||||||:|.....:..::| :|  ::.|||:.. |.
  Fly   130 VITEDAQRFAKQMD--------IELFETSAKDNINVENMFLSITRQVL-DHKLRTSPNEQQK-DT 184

Human   209 IKLDQETLRAENKSQCC 225
            :.| :...:.....:||
  Fly   185 LHL-KPNPKGSKGGKCC 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB32	NP_006825.1	Rab32_Rab38	26..224	CDD:206692	68/206 (33%)
		Switch 1. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	48..62		7/13 (54%)
		Switch 2. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	84..97		7/12 (58%)
		PKA-RII subunit binding domain	178..197		6/20 (30%)
Rab35	NP_608373.1	Rab35	3..201	CDD:133310	72/212 (34%)