Protein Alignment COPS6 and CSN6

DIOPT Version :9

• Sequence 1: NP_006824.2
• Gene: COPS6 / 10980
• HGNCID: 21749
• Length: 327
• Species: Homo sapiens
• Sequence 2: NP_524451.1
• Gene: CSN6 / 42661
• FlyBaseID: FBgn0028837
• Length: 341
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 191/332 - (57%)
• Similarity: 255/332 - (76%)
• Gaps: 9/332 - (2%)

Human     4 AAAAAAATNGTGGSSGMEVDAAVVPS-------VMACGVTGSVSVALHPLVILNISDHWIRMRSQ 61
            :|..:.:::...||| |.||.....:       :.|.|.:|||:::||||||:|||:||.|.|:|
  Fly    11 SAKPSTSSSAAAGSS-MAVDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWTRFRAQ 74

Human    62 EGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYT 126
            .|.|.||.|||||||:|||||:||||||.:..:.::.:|:|:||..||:|:||||.:|:|:||||
  Fly    75 HGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWYT 139

Human   127 TGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTD-LPVSVFESVIDIINGEATMLFAELTYTL 190
            ||..|...||.:.:|:..|.|.|:.|:|||:::..| ||:.:|||:||:::|||||||..|||||
  Fly   140 TGDNPTADDIKIQRQIAAINECPIMLQLNPLSRSVDHLPLKLFESLIDLVDGEATMLFVPLTYTL 204

Human   191 ATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHE 255
            |||||||||||||||||:..|||.|.|||||:||.||||||::|:|::|:|::..|||::..|.|
  Fly   205 ATEEAERIGVDHVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQE 269

Human   256 ILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGR 320
            ||||||||||.|||:....|:.:||.|||||||::||||:||.||.|:.||||||:||||||..|
  Fly   270 ILREAYALCHRLPVMQVPAFQEEFYTQCNDVGLISYLGTLTKGCNDMHHFVNKFNMLYDRQGSAR 334

Human   321 RMRGLFF 327
            |||||::
  Fly   335 RMRGLYY 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COPS6	NP_006824.2	MPN_CSN6	39..321	CDD:163694	174/282 (62%)
		Interaction with Vpr	211..327		76/115 (66%)
CSN6	NP_524451.1	MPN_CSN6	52..335	CDD:163694	174/282 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147333
Domainoid	1	1.000	158	1.000	Domainoid score	I4136
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4977
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1975
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55514
OrthoDB	1	1.010	-	-		D1455324at2759
OrthoFinder	1	1.000	-	-		FOG0005913
OrthoInspector	1	1.000	-	-		oto90844
orthoMCL	1	0.900	-	-		OOG6_103125
Panther	1	1.100	-	-	LDO	PTHR10540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4523
SonicParanoid	1	1.000	-	-		X4896
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800