Protein Alignment FERMT2 and Fit2

DIOPT Version :10

• Sequence 1: XP_006720071.1
• Gene: FERMT2 / 10979
• HGNCID: 15767
• Length: 706
• Species: Homo sapiens
• Sequence 2: NP_648947.1
• Gene: Fit2 / 39907
• FlyBaseID: FBgn0036688
• Length: 715
• Species: Drosophila melanogaster
• Alignment Length: 747
• Identity: 328/747 - (43%)
• Similarity: 474/747 - (63%)
• Gaps: 94/747 - (12%)

Human    15 DGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTL 79
            :.:|.|.:.:|||..:.|:||.|:.||||:||:||:. :..||||||||||..:..||.:|..||
  Fly     6 ENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPARNVWLSRTKLTL 69

Human    80 DKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKK- 143
            |:.|:|||:.|.|||.||:||:|||:::|:..:|::|.:.|.||.::||..:||:||||||.|.
  Fly    70 DQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPL 134

Human   144 PRDPTKKKKKKLDDQSEDEALELEG-PLITPGSGTDVLYIGPLKGSIY---SSPGLYSKTMTPTY 204
            ..:..|:...::..|......|.:| ..:.|.:.|:...  |:..|.:   .|.|...|...|
  Fly   135 EAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFV--PISTSFHGEGGSTGSLDKPSAP-- 195

Human   205 DAHDGS----PLSPTS------------------------AWFGDSALSEGN-PGILAVSQPITS 240
                ||    ||||.:                        |.:..|:.|.|: ...||.|.|...
  Fly   196 ----GSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPC 256

Human   241 PEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQL 305
            .::.|...:|::|::||::|.||||||.|:|||.::|.:.|.|||||::|||||||.|.:|||||
  Fly   257 ADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQL 321

Human   306 YEQAKWAILLEEIECTEEEMMMFAALQYHIN------------KLSIMTSENHLNNSDKEVDEVD 358
            ||||||::|.||::|||||.:||||||:.:|            ...|.||....:|.    ||:|
  Fly   322 YEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE----DEID 382

Human   359 AALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEE 423
            :||.:|:|||||........:||.||||:||::..||::.||:|||:|:.|::|..:..:|:.|:
  Fly   383 SALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAED 447

Human   424 SSG-TPAHQMNLRGCEVTPDVNISGQKFNIKLLIPV--AEGMN-EIWLRCDNEKQYAHWMAACRL 484
            |.. .||..:||:|||||||||:|..|:.|:|.:..  ..|:| |:|:||:||:|||.|||||||
  Fly   448 SRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRL 512

Human   485 ASKGKTMADSSYNLEVQNILSFLKMQ------HLNPDPQLIPEQITTDITPECLVSPRYLKKYKN 543
            |:||:::|||||..||.:|||.|:||      |:|.||:.: |.:.       .:||:.::|..|
  Fly   513 AAKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSV-EAVD-------YLSPKIIRKLSN 569

Human   544 KQEKGCKKHMPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKK 608
            |                ...||||||.||.:::.:::|:::||||:|||:||::.||.:|.|.:|
  Fly   570 K----------------AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRK 618

Human   609 EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVH 673
            |||:|:|:||::|||.|:||.|||||::.||.|||||.||.:.::|.|| .:.|.|...||||||
  Fly   619 EELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVH 682

Human   674 EFIGGYIFLSTRAKDQNESLDEEMFYKLTSGW 705
            ||||||||:|.|:||.|::|:||:|:|||.||
  Fly   683 EFIGGYIFMSMRSKDTNQTLNEELFHKLTGGW 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FERMT2	XP_006720071.1	FERM_F0_KIND2	17..96	CDD:340701	41/78 (53%)
		FERM_F1_KIND2	97..288	CDD:340704	71/224 (32%)
		B41	<252..>335	CDD:214604	54/82 (66%)
		PH_fermitin	384..508	CDD:269943	66/127 (52%)
		FERM_M	<466..599	CDD:459788	59/138 (43%)
		FERM_C_fermitin	593..684	CDD:270026	53/90 (59%)
Fit2	NP_648947.1	FERM_F0_kindlins	8..86	CDD:340615	41/78 (53%)
		FERM_F1_kindlins	87..304	CDD:340616	71/224 (32%)
		B41	259..>351	CDD:214604	56/91 (62%)
		PH_fermitin	408..536	CDD:269943	66/127 (52%)
		FERM_M	<507..609	CDD:459788	50/125 (40%)
		FERM_C_fermitin	603..693	CDD:270026	53/90 (59%)