DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASCC3 and l(3)72Ab

DIOPT Version :9

Sequence 1:XP_011533696.1 Gene:ASCC3 / 10973 HGNCID:18697 Length:2207 Species:Homo sapiens
Sequence 2:NP_648818.3 Gene:l(3)72Ab / 39737 FlyBaseID:FBgn0263599 Length:2142 Species:Drosophila melanogaster


Alignment Length:2235 Identity:855/2235 - (38%)
Similarity:1260/2235 - (56%) Gaps:228/2235 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    20 DNYNEEVADLKVDLLKIKRSKLHEQVLDL----GLTWKKIIKFLNEKLE-------KSKMQSINE 73
            |.|.....: |.:..|:||.|..|...|.    |.|      .|:|.::       :.|.|...:
  Fly    54 DRYQRTKPE-KTEERKVKRQKRDEAQYDFERMKGAT------LLSEGIDEMVGIVYRPKTQETRQ 111

Human    74 DLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKA-IKQMFGPFPSSSATAACN 137
            ..:.:|...::.:| |..|: |..|||...:.....|.:..:|.|. |..:.|...........|
  Fly   112 TYEVLLSFIQEALG-DQPRD-ILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVN 174

Human   138 ATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAF--SFDMHDLDHF-----DELPINGETQK 195
            ...: |:.|..|.:.||......|......:|.|:.|  |.:..|.|.:     |:....||..:
  Fly   175 LGKK-ITDFGSDAVNALTAAPNNEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQDEGEEAR 238

Human   196 TISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKY-----LNSTLKE-MTEVPRVEDLCC 254
               :|:    ..|.:.....|.....|...|....:::.|     |:...|: |....:..|:..
  Fly   239 ---IDH----TLHAENLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLK 296

Human   255 TLYDMLASIKSGD--ELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKK 317
            .|.|      :.|  :.:::|..|||.:..:.|::|..||..::                 .|..
  Fly   297 ILKD------AADDRDCENQLVLLLGYDCFDFIKQLKLNRQMVL-----------------YCTM 338

Human   318 ILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIAR--REKKAGEDLEVSEGLMCFDPKELRIQ 380
            :            .:.|::.|:|.:::..|....:|:  |:...|:..:..||            
  Fly   339 L------------ASAQTDSERQRIREKMRGNSALAKILRQLDTGKSEDQEEG------------ 379

Human   381 REQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEA------------------MKTSAFIAGA 427
                  .||.    |::...|.|        |..|.|                  .:.|.|:|..
  Fly   380 ------EARG----SKRGKGDAE--------DGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANK 426

Human   428 KMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFET 492
            :..||:|..|:..|.||||.:|..:|:|....|:...:..|.:..|..|:|.|.||||||.:::.
  Fly   427 RCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKA 491

Human   493 AYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHF-QQGVIKKNEFKIVYVAPMKALAAEMTDYFS 556
            |.:::||||:||||||||||:|:||::.||.:|. :.|.|...:|||:||||||:|..||...|.
  Fly   492 ALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFG 556

Human   557 RRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLL 621
            |||....:.|.|||||.||::.:|..||::|.||||||::|||. |:.....:|||:|:||:|||
  Fly   557 RRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKG-GERTFVSLVRLVIIDEIHLL 620

Human   622 HEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPL 686
            |::||||||::||||:|.:|:||..:|::|||||||||.||||||.|.|..|||:||..:|||.|
  Fly   621 HDERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSL 685

Human   687 GQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAG-HQVMVFVHARNATVRTAMSLIERAKNCGHI 750
            .|.::|:.....:::...|:|:.||..::.  || :||:||||:|..|.:||.::.:.......:
  Fly   686 EQQYIGVTEKKALKRFQVMNEIVYEKTMEH--AGRNQVLVFVHSRKETGKTARAVRDMCLEQDTL 748

Human   751 PFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTA 815
            ..|.........:...:.::.:|.:::||.|.||:||||||.|.||.|||:||::.||:|||.||
  Fly   749 GSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTA 813

Human   816 TLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSH 880
            |||||||||||.|||||||:|..::|.:|:|..|||:|:.|||||||:|..||||:||.|.:|..
  Fly   814 TLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQF 878

Human   881 YLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAY 945
            ||:||.|:.||||||:..|.|.|||||.||||.::::||.|:.|||||:||..||..||:||.|.
  Fly   879 YLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSHDAI 943

Human   946 QIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAH 1010
            :.||.|.:||..|:......|:::.:|:::.:||:|..|||||.|||||:.:.|:.|:|:|....
  Fly   944 KADPLLEQHRADLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLLKQT 1008

Human  1011 KTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEM 1075
            .:|.::|.:.|.:.||..|.|||||..||..|:.. ..:.....:|....|:|:|||.|||:.::
  Fly  1009 LSEIELFRVFSLSSEFRHISVREEEKLELQKLMER-VPIPIKESIEEHSAKVNVLLQAYISQLKL 1072

Human  1076 DSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPP 1140
            :.|:|:||..::.|:|||::||:|||.|.:.|..:..:.|.|.|:||:|:|...:|||||..:|.
  Fly  1073 EGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPD 1137

Human  1141 HILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTL 1205
            .|..:||:|.....:|.|:...|:|.::....:|..:.:.|||.|.:.:...||||||..|||.|
  Fly  1138 EIAKKLEKKHFPWGRLYDLEPHELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRVEL 1202

Human  1206 SIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPS 1270
            :|..||.|:::|||. .|.:|:.:||..::.|.|.|:||.  ||..|::...|.|.:|:|||||.
  Fly  1203 TITPDFQWDEKVHGQ-SEGFWVLIEDVDSELILHHEFFLL--KQKYSQDEHQLKFFVPVFEPLPP 1264

Human  1271 QYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYN--FSHFN 1333
            ||::|.|||||:|||....::|:||||||::.|.|||||||||||:||....:|:.|:  |..||
  Fly  1265 QYFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFN 1329

Human  1334 PVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWK 1398
            |:|||:|:.:|::|.||.:||||||||...||.||.|:|.....::.||:...:||......|| 
  Fly  1330 PIQTQVFNAVYNSDENVFVGAPTGSGKMTIAEFAIMRLFTTQSDARCVYLVSEEALADLVFADW- 1393

Human  1399 VRIEEKLGK---KVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEI 1460
               ..|.|.   ||::|||:...|:|.|||..|::||.:|||.:||.|:.|..||.|.:.|:||:
  Fly  1394 ---HSKFGSLDIKVVKLTGETGTDLKLIAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDEL 1455

Human  1461 HLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPV 1525
            .|:|.|.|||||::.||..:|||..||.:|||.||.:|.:|||:|.||.......|||.|||||:
  Fly  1456 QLVGGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPI 1520

Human  1526 PLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDP 1590
            |||:||||:...|...|:|:|:||.:.||..:|..|||::|||||:|.||||::::.:.|::..|
  Fly  1521 PLELHIQGYNVTHNATRIATMSKPVYNAILKYSAHKPVIVFVSSRKQARLTAIDVLTYAASDLQP 1585

Human  1591 KQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLA 1655
            .::.:.:|.:::..:..:.|..||.|||.|:...|.||...|.:.||:||.:..|||.:.:..|.
  Fly  1586 NRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDLC 1650

Human  1656 WGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKK 1720
            ||::..||||||..|::|:||...|.|:||||||||:|||.||..|...|.|::....||||:||
  Fly  1651 WGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKK 1715

Human  1721 FLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSV 1785
            |:.||.|:||.|...:.||.|||:...||.:||||:||:|||:.:|||..||:||||..|:|..:
  Fly  1716 FINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHL 1780

Human  1786 NKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEEL 1850
            :..||.|:|.:|.:||.|.||.: ||:....||..|.||:|||:.:.|:::|...|..:.....|
  Fly  1781 SDHLSELVENTLSDLEQSKCISV-EDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGL 1844

Human  1851 LSILSDAEEYTDLPVRHNEDHMNSELAKCL------PIESNPHSFDSPHTKAHLLLQAHLSRAML 1909
            |.|:|.|.||.|:.|||:|:.:...|::.|      |.|:.| .|:.||.|.:|||||||||..|
  Fly  1845 LEIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTGPNETAP-KFNDPHIKTNLLLQAHLSRLQL 1908

Human  1910 PCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIEN 1974
            . |:...||:.:|.:|:|:.||.:||.::.|||...:....|.|||.|..|.|||.|..||:.. 
  Fly  1909 G-PELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFS- 1971

Human  1975 HHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGK--DHVFSSM-VESE-------LHAAKTK 2029
                                       ||::..|..|  :.||..| :|.|       |...:..
  Fly  1972 ---------------------------PEIVKRCTEKKIETVFDIMELEDEDRTRLLQLSDLQMA 2009

Human  2030 QAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRV 2094
            ....|.:..|.|.:...|       |:.....|.||:       |..::|..:.|....|     
  Fly  2010 DVARFCNRYPNIELNYEV-------VDKDRINSGSTV-------NVVVQLEREDEVTGPV----- 2055

Human  2095 HFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGR 2159
                         :.|.||:.::|||::::|:.....|:::||: .::......|.|..|. ||:
  Fly  2056 -------------IAPFFPQKREEGWWVVIGDPKTNSLLSIKRL-TLQQKAKVKLDFVAPS-PGK 2105

Human  2160 YIYTLYFMSDCYLGLDQQYDIYLNV 2184
            :.||||:|||.|||.||:|...:.|
  Fly  2106 HDYTLYYMSDSYLGCDQEYKFSIEV 2130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASCC3XP_011533696.1 BRR2 465..1244 CDD:224125 363/780 (47%)
DEAD 483..661 CDD:278688 100/178 (56%)
HELICc 783..861 CDD:197757 53/77 (69%)
Sec63 983..1291 CDD:280962 126/307 (41%)
BRR2 1332..2061 CDD:224125 309/747 (41%)
DEAD 1333..1504 CDD:278688 81/173 (47%)
HELICc 1619..1698 CDD:197757 38/78 (49%)
SEC63 1814..2183 CDD:214744 117/384 (30%)
l(3)72AbNP_648818.3 BRR2 466..1241 CDD:224125 364/779 (47%)
DEAD 482..661 CDD:278688 100/179 (56%)
HELICc 773..859 CDD:197757 56/85 (66%)
Sec63 982..1285 CDD:280962 126/306 (41%)
DEXDc 1320..1506 CDD:214692 88/189 (47%)
DEAD 1329..1495 CDD:278688 79/169 (47%)
HELICc 1615..1694 CDD:197757 39/78 (50%)
Sec63 1811..2127 CDD:280962 117/379 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1204
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54133
OrthoDB 1 1.010 - - D154891at2759
OrthoFinder 1 1.000 - - FOG0001085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100305
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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