DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERP29 and wbl

DIOPT Version :9

Sequence 1:	NP_006808.1	Gene:	ERP29 / 10961	HGNCID:	13799	Length:	261	Species:	Homo sapiens
Sequence 2:	NP_001286609.1	Gene:	wbl / 37206	FlyBaseID:	FBgn0004003	Length:	257	Species:	Drosophila melanogaster

Alignment Length:	257	Identity:	81/257 - (31%)
Similarity:	137/257 - (53%)	Gaps:	16/257 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    18 LLGFLLLSAPHG---GSGLHTKGALPLDTVTFYKVIPKSKFVLVKFDTQYPYGEKQDEFKRLAEN 79
            :|..|||.|.|.   ...:...|.:.||.::|.|.:.:..:.:||||..||||||.:.|...:::
  Fly     4 ILVTLLLVAIHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEKHEAFTAFSKS 68

Human    80 S-ASSDDLLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYLFR-DGDFENPVPYTGAVKVGAIQ 142
            : .::.|||:|.||:.|||:..|..|.::||:|.:::|..:||: :.|....:|....|.:..::
  Fly    69 AHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPSHVDVTLDNLK 133

Human   143 RWLKGQ-GVYLGMPGCLPVYDALAGEFIRASGVEARQAL--LKQGQDNLSSVKETQKKWAEQYLK 204
            .::... .:|:|..||:..::.:...:......|..:.:  |:..|:.|:..::.|.  |..||.
  Fly   134 AFVSANTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQAKQEQLTDPEQQQN--ARAYLI 196

Human   205 IMGKILDQGEDFPASEMTRIARLIEKNKMSDGKKEELQKSLNILTAFQ-----KKGAEKEEL 261
            .|.||.:.|.||...|..|:.|| :..|:::.|||||.:.||||..|:     |...|||||
  Fly   197 YMRKIHEVGYDFLEEETKRLLRL-KAGKVTEAKKEELLRKLNILEVFRVHKVTKTAPEKEEL 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERP29	NP_006808.1	PDI_a_ERp29_N	36..149	CDD:239305	36/115 (31%)
		ERp29	156..251	CDD:311614	30/96 (31%)
		ER retrieval sequence	258..261		2/2 (100%)
wbl	NP_001286609.1	ERp29_N	22..147	CDD:254509	38/124 (31%)
wbl	NP_001286609.1	ERp29	149..242	CDD:285048	29/95 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141561
Domainoid	1	1.000	76	1.000	Domainoid score	I9012
eggNOG	1	0.900	-	-		E1_28K2V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4963
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4811
Isobase	1	0.950	-	0	Normalized mean entropy	S7243
OMA	1	1.010	-	-		QHG59606
OrthoDB	1	1.010	-	-		D1535651at2759
OrthoFinder	1	1.000	-	-		FOG0012441
OrthoInspector	1	1.000	-	-		oto90636
orthoMCL	1	0.900	-	-		OOG6_109017
Panther	1	1.100	-	-	LDO	PTHR12211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4822
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.750