Protein Alignment PDIA5 and Tmx3

DIOPT Version :10

• Sequence 1: NP_006801.1
• Gene: PDIA5 / 10954
• HGNCID: 24811
• Length: 519
• Species: Homo sapiens
• Sequence 2: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Alignment Length: 258
• Identity: 61/258 - (23%)
• Similarity: 101/258 - (39%)
• Gaps: 48/258 - (18%)

Human   278 VYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKA 342
            |..|:|...|  |:.....||||:|||||:|||.:|.|...|:|||......|.|   |.|...|
  Fly    28 VLELSDRFID--VRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATNVRVGRL---DCTKYPA 87

Human   343 LAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNF 407
            .|:.|.:..:||:.:.|...::.....|.:.:.:::......||             :.||....
  Fly    88 AAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPP-------------VQLVTRTE 139

Human   408 RETLKKKKHTLVMFY------APWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQ 466
            ...:.|..||:...:      ..|        ..:.|.|:.:::.......:.| :..::.|..:
  Fly   140 SVDMLKGSHTIFFIFVGQQEGVVW--------DTYYAAAEGYQEHGFFYATSED-IAAQHFDFEK 195

Human   467 QEAVKGY--PTFHYYHYGKFAEKYDSDRTELG-----------FTNYIRALREGDHERLGKKK 516
            ..||..|  ...|:|.:|..|  ::.|..|:.           ||.:.:..|...|:.|...|
  Fly   196 LPAVIVYKEEQHHFYPHGHLA--HEMDPNEVNETVFQWVNVERFTLFPKVTRFNIHQLLKTNK 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365
		PDI_a_PDIR	152..256	CDD:239295
		PDI_a_PDIR	277..379	CDD:239295	34/100 (34%)
		PDI_a_PDIR	398..501	CDD:239295	21/121 (17%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	516..519		1/1 (100%)
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	34/104 (33%)
		ER_PDI_fam	28..>355	CDD:273457	61/258 (24%)