DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDIA5 and CaBP1

DIOPT Version :9

Sequence 1:	NP_006801.1	Gene:	PDIA5 / 10954	HGNCID:	24811	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	102/421 - (24%)
Similarity:	171/421 - (40%)	Gaps:	92/421 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   130 SIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQK 194
            |:.||.....|            ||.| :..:|.|.:.|::...::.||||||..|:.::|.::|
  Fly    16 SVSAFYSPSDG------------VVEL-TPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKK 67

Human   195 AATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNP 259
            .|..|:|...:..:|..:.  ..:..::.|||||||..|            |:..:...::  |.
  Fly    68 LAKALKGVVKVGSVNADAD--STLSGQFGVRGFPTIKIF------------GANKKSPTDY--NG 116

Human   260 QPPQPQVPETPWAD----------------EGGS-------VYHLTDEDFDQFVKEHSSV-LVMF 300
            |.....:.|...|:                .|||       |..||:::||:.|.....: ||.|
  Fly   117 QRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEF 181

Human   301 HAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYA 365
            .||||||||.:.||:.|||:.|.|:..    |.|:|||.:::.|..:::..:||:|:|..|.|.|
  Fly   182 FAPWCGHCKNLAPEWAKAAKELKGKVK----LGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRA 242

Human   366 VPVL-----RTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPW 425
            ....     ||....:.|..:......|.|       .::.::.::..||..:.|...|:...|.
  Fly   243 SDAQEYDGGRTASDIVSWASDKHVANVPAP-------ELIEIINESTFETACEGKPLCVVSVLPH 300

Human   426 CPHC-----KKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVK----GYPTFHYYHY 481
            ...|     .|.:.......:.||..:.....|     :..|.|..:|:::    |||.....::
  Fly   301 ILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWA-----EGGQQLALEESLEVGGFGYPAMAVVNF 360

Human   482 GK-----FAEKYDSDRTELGFTNYIRALREG 507
            .|     ....:..|    |...::|.:..|
  Fly   361 KKMKFSVLKGSFSKD----GINEFLRDISYG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365	3/8 (38%)
		PDI_a_PDIR	152..256	CDD:239295	28/103 (27%)
		PTZ00102	168..512	CDD:240266	93/383 (24%)
		PDI_a_PDIR	277..379	CDD:239295	40/114 (35%)
		PDI_a_PDIR	398..501	CDD:239295	19/116 (16%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	516..519
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	31/121 (26%)
		PDI_a_P5	157..262	CDD:239299	40/108 (37%)
		Thioredoxin_6	190..383	CDD:290560	45/212 (21%)
		P5_C	271..400	CDD:239281	22/133 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810