DRSC/TRiP Functional Genomics Resources

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Protein Alignment MSL3 and msl-3

DIOPT Version :9

Sequence 1:NP_523353.2 Gene:MSL3 / 10943 HGNCID:7370 Length:521 Species:Homo sapiens
Sequence 2:NP_523951.1 Gene:msl-3 / 38779 FlyBaseID:FBgn0002775 Length:512 Species:Drosophila melanogaster


Alignment Length:546 Identity:148/546 - (27%)
Similarity:239/546 - (43%) Gaps:118/546 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    11 FHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRD 75
            ||.||.|||:|||.:||||||.:|:::|...::|.|.:..||.|||.||..|:||......:|:|
  Fly    11 FHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKD 75

Human    76 TDENRRLQRKLARKAVARLRS-----------TGRKKKRCRLPGVDSVLKGLPTEEKDENDENSL 129
            |:|||:|||:||..|..::|.           :.:||:..:...|:..:. :|.:......|:.:
  Fly    76 TEENRQLQRELAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIV-VPMDTGHLEAEHEM 139

Human   130 SSSSDCSENKDEEISEESDIEEKTEVKEEP-----ELQTRREMEERT------------------ 171
            :.:...:.|:..:.|       ..:.||:|     .|:..|..:..|                  
  Fly   140 APTPRAAGNRTRDNS-------GGKRKEKPPSGDGRLKGNRGRQTETFYNNAINDVSVYNHVPQE 197

Human   172 --ITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANE---RPRH 231
              |.:.:.|.|::.:|.|...|....:...||.:..|:||:|::||..|:..|.|..:   |.|:
  Fly   198 DRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARN 262

Human   232 HHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQY--KKVTSSKFFLPI 294
            .. ..:|.|...|......|.:.||:||||||.|::.:...|||. |:.:|  ..:|...    :
  Fly   263 TQ-SRNARMEREYDRVMSTVCMLKEVVDGLRIYFEFHVDDHLLYT-EEKEYVHNYLTDDN----M 321

Human   295 KESATSTNRSQEELSPS--PPLLN-PSTPQSTESQPTTGEPAT-----PKRRKAEPEA-LQSLRR 350
            :..:...|:|.|.::||  ..|:. ..||....|..|.|:...     |:..|...:. |..:..
  Fly   322 RNCSLILNKSYEYINPSGDTELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTA 386

Human   351 STRHSANC-DRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVF 414
            |.:::|.. :|.|..:|:                      .|.||..|                 
  Fly   387 SGKNTAQAYERTSPYTAA----------------------YKLPVEMR----------------- 412

Human   415 AGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKA 479
             ||       :||...|:|:     ..:.||..|.::||.||:||.:|:|..|.....|.|.|:.
  Fly   413 -GF-------LNETFKWRLL-----SAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLED 464

Human   480 LLKHFDLFLRFLAEYHDDFFPESAYV 505
            ||.|.|.|:.:| |.|.::|....:|
  Fly   465 LLPHLDAFINYL-ENHREWFDRENFV 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MSL3NP_523353.2 CBD_MSL3_like 15..81 CDD:350846 32/65 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..166 8/56 (14%)
MRG 156..506 CDD:399022 98/390 (25%)
Required for the histone acetyltransferase activity of the MSL complex 290..440 29/159 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..409 23/120 (19%)
msl-3NP_523951.1 MRG 196..486 CDD:283390 91/348 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149766
Domainoid 1 1.000 84 1.000 Domainoid score I8259
eggNOG 1 0.900 - - E1_KOG3001
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H40749
Inparanoid 1 1.050 155 1.000 Inparanoid score I4316
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47495
OrthoDB 1 1.010 - - D1624495at2759
OrthoFinder 1 1.000 - - FOG0006694
OrthoInspector 1 1.000 - - otm40653
orthoMCL 1 0.900 - - OOG6_108548
Panther 1 1.100 - - LDO PTHR10880
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4670
SonicParanoid 1 1.000 - - X4893
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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