Protein Alignment UGT2A1 and Ugt36A1

DIOPT Version :9

• Sequence 1: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_001285591.1
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 128/526 - (24%)
• Similarity: 250/526 - (47%)
• Gaps: 58/526 - (11%)

Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPV--NFEVIPVSYKKSNIDSLIEHMIML 303
            ||:..:..||.||..|.|::||::     :: .||.:..  |:|.:.:|....:..|...:::.|
  Fly    39 SHFKVVMPILNELAHRGHDITVIS-----YV-KNPQAGAYPNYEELLISAPGEDQSSTTINLVPL 97

Human   304 WIDHRPTPLTIWAFYKELGKLLDTFFQINIQ---LCDGVLKN---PKLMARLQKGGFDVLVADPV 362
             .:|.||        :.||.|:..:..::.:   .|:.:..:   .:.:.|.:...:|:|:.:..
  Fly    98 -TEHTPT--------RSLGVLIREYVDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYF 153

Human   363 -TICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAP--VSYVPAALSELTDQMTFGERIKNTI 424
             :.|...:|..|.:|.   :..|..:.:..:..:|..|  .:::.:.......|:.:.||:.|.:
  Fly   154 NSDCQLALAKLLNLPI---IGLSTCALMPYYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFV 215

Human   425 SYSLQDYIFQSYWGEW-NSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEF---------PRPYL 479
            ...|..::::.:.... |....|.||....:.|        :.||...|.|         .||..
  Fly   216 QAKLLKFLYKYHSNRADNELVRKYLGVEVDVEE--------VARTQTAFIFGNQHYSLMGSRPQS 272

Human   480 PNFEFVGGLHC--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NLTEEKANLIASALAQIP 540
            ..|..:||:|.  |..:.||:.:..|:..|.: ||:..|.||||:  ::.|:|.:.|...|...|
  Fly   273 LQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQP 336

Human   541 QKVLWRYKG-KKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMF 604
            .|::|:::. :.|.|..:......|.||..||.|||.|.|.:|||..|..|:::.|.|::..|::
  Fly   337 LKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIY 401

Human   605 ADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAV 669
            .||..|...::.:|..::::...:|..:|..|| ..:::.||.:.::.:|::.:::...||:.|:
  Fly   402 GDQFLNAFSVQNRGMGLKLDYQDITVPNLKKAL-AELSKNSYAQRSLEVSKVFNERQQTPLESAI 465

Human   670 FWIEFVMRHK--GAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFG--KI 730
            :.:|.|:.:.  .|:.|:....:|..|.|||||.:..:|:.:...|.::...|..:..|..  |:
  Fly   466 WSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLILLILVLCYLCKRNPSKLAHKKV 530

Human   731 GKKKKR 736
            |||.||
  Fly   531 GKKPKR 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	121/511 (24%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	109/463 (24%)
		UDPGT	38..501	CDD:278624	118/489 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840