Protein Alignment AFG3L2 and AFG3

DIOPT Version :10

• Sequence 1: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_010933.1
• Gene: AFG3 / 856737
• SGDID: S000000819
• Length: 761
• Species: Saccharomyces cerevisiae
• Alignment Length: 821
• Identity: 384/821 - (46%)
• Similarity: 497/821 - (60%)
• Gaps: 102/821 - (12%)

Human     6 LRLWGRGGCWPRGLQQLLVPGGVGPGE-----QPCLRTL----YRFVTTQARASRNSL-----LT 56
            :.:|.|   :.||..:.|.....|...     :|.||:.    .|..|....|:||::     :.
Yeast     1 MMMWQR---YARGAPRSLTSLSFGKASRISTVKPVLRSRMPVHQRLQTLSGLATRNTIHRSTQIR 62

Human    57 DIIAAYQRFC-SRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGG 120
            ....::.|.. :||.|..|     |||                         :|.......|..|
Yeast    63 SFHISWTRLNENRPNKEGE-----GKN-------------------------NGNKDNNSNKEDG 97

Human   121 KKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKR-------SGREITWKDFVNN 178
            |...:.:.|..:.    :..|:|......|..|  .::|.||...       |.|.:|::||...
Yeast    98 KDKRNEFGSLSEY----FRSKEFANTMFLTIGF--TIIFTLLTPSSNNSGDDSNRVLTFQDFKTK 156

Human   179 YLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPV 243
            ||.||:|.::.||||..|.......|     |.|.|.|||||.||..::.:|..|.|...:|:|:
Yeast   157 YLEKGLVSKIYVVNKFLVEAELVNTK-----QVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPI 216

Human   244 VYIAESDG-SFLLSMLPTVLIIAFLLYTIRR----GPAGIGRTGRGMGGLFSVGETTAKVLKDEI 303
            .||..|.. :||...|||::::..|.:..|:    .|...|..|.|:||:|:||::.||:...|.
Yeast   217 KYIERSSPFTFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKET 281

Human   304 DVK--FKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 366
            |:|  ||:||||:|||.||||||:|||||.:|..||||||:||||:|||||||||||||||||||
Yeast   282 DIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGEAN 346

Human   367 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNF--GGQSEQEN 429
            |||::||||||:|||||||.:||||||..||..||.|:|||||||:|::||:|..  |...|:|.
Yeast   347 VPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDEREA 411

Human   430 TLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPL 494
            ||||||||||||.|:..||:||||||||:||.||:|||||||.|.|..||:.||..|:.|||:.|
Yeast   412 TLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLKRL 476

Human   495 KLDSTLEKD--KLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLE 557
            .||..|..|  .|:.|||:|||||:|||:||.|||||||||||....|...||||||||||.|||
Yeast   477 NLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVIAGLE 541

Human   558 KKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKG-LGYAQYLPKEQYLYTKEQL 621
            |||:||..|||::||||||||||.||:|::|||||||||||||:| ||||||||.:|||.::||.
Yeast   542 KKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQYLPPDQYLISEEQF 606

Human   622 LDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLE 686
            ..||.|.||||||||:.|..:|:||.||.:||||.|.|.:...||:.|:|.:||| ...|:..:.
Yeast   607 RHRMIMALGGRVSEELHFPSVTSGAHDDFKKVTQMANAMVTSLGMSPKIGYLSFD-QNDGNFKVN 670

Human   687 KPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFA 751
            ||:|..|||.||.||:.:::||::....|||:....|:.||..||.||.:.:.||:.|||||||.
Yeast   671 KPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKVDLVAKELLRKEAITREDMIRLLGPRPFK 735

Human   752 EKS-TYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPP 791
            |:: .:|::::                      .|...|||
Yeast   736 ERNEAFEKYLD----------------------PKSNTEPP 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126		7/49 (14%)
		HflB	151..747	CDD:440233	343/614 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797		4/33 (12%)
AFG3	NP_010933.1	FtsH_ext	124..215	CDD:377663	34/97 (35%)
		FtsH_fam	223..730	CDD:273520	304/507 (60%)