Protein Alignment AFG3L2 and Rpt3R

DIOPT Version :10

• Sequence 1: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_649938.2
• Gene: Rpt3R / 41190
• FlyBaseID: FBgn0037742
• Length: 405
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 111/287 - (38%)
• Similarity: 160/287 - (55%)
• Gaps: 23/287 - (8%)

Human   293 ETTAKVLK--DEIDVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGK 354
            ::|..:|.  ::.|:.:.|:.|.:..|.||.|.|.. |.:.:.|:.:|...|:|.:|.||||.||
  Fly   135 DSTISMLSPDEKPDISYSDIGGLDIQKQEIREAVELPLTHAQLYKQIGIDPPRGVLLFGPPGCGK 199

Human   355 TLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRG 419
            |:||||.|......||.|.||||::.::|.||..|||||.||::|:|.|:|||||||:..||...
  Fly   200 TMLAKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDLFRLAKQNSPSIIFIDEIDAIATKRFDA 264

Human   420 NFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRA 484
            ..|...|.:..|.:||.:||||:.|||:.::..|||.|.||||||||||.||:|.:..||.:.:.
  Fly   265 QTGADREVQRILLELLNQMDGFDETTNIKVIMATNRADTLDPALLRPGRLDRKIELPLPDRRQKR 329

Human   485 SIFKVHLRPLKLDSTLE-KDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQA 548
            .:|......:.:...:: :|.:||     ....|.||:..:|.||.:.|.|.....:|.|.||:.
  Fly   330 LVFTTITSKMNVGEDVDLEDIIAR-----PDKISNADINAICQEAGMHAVRENRYVVNAKDFEKG 389

Human   549 IERVIGGLEKKTQVLQPEEKKTVAYHE 575
            .         ||.|     :|..|.||
  Fly   390 Y---------KTSV-----RKDEAQHE 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126
		HflB	151..747	CDD:440233	111/287 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797
Rpt3R	NP_649938.2	PTZ00454	20..405	CDD:240423	111/287 (39%)