Protein Alignment AFG3L2 and Spg7

DIOPT Version :10

• Sequence 1: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 748
• Identity: 320/748 - (42%)
• Similarity: 442/748 - (59%)
• Gaps: 76/748 - (10%)

Human    68 RPPKGFEKYFPNGKNGKKASEPKE-------VMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDS 125
            :|.||..|...:....||::...|       ..||:..|.|  |:.|:.|..|....:...::|.
  Fly    98 QPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTP--TSSSTIGEPGEDPNKNSNENDE 160

Human   126 HWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLL--------KRSGREITWKDFVNNYLSK 182
            ...|...|.            .||....:..|.|:.||        :.|.|.::|.:||::.|:.
  Fly   161 KMRSVLTKA------------VLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAV 213

Human   183 GVVDRLEV-VNKRFVRVTFTPGKTPVDGQYV---WFNIGSVDT--FERNLETLQQELGIEGENRV 241
            |.|..|.: .:...|.:....|.. :.|:.|   .|::...|.  ||..|..:::.|||  ::.|
  Fly   214 GEVKELIIRPDMEMVTIILHEGAV-IKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGV 275

Human   242 PVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAK-VLKDEID- 304
            ||.|..::|.:..:.||   |::..||.:|......| ::...|.....:|.  || .|.|..|
  Fly   276 PVTYDRQTDTTGRILML---LLVCALLMSIATRMKSI-KSPLSMDSFNQMGR--AKFTLVDPFDG 334

Human   305 ---VKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 366
               |.|:||||..|||.|:.|||::||:|::||.||||:|:||:|.||||.||||||||.|.||.
  Fly   335 GRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQ 399

Human   367 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKR------GRGNFGGQS 425
            |||::::||||:||..|:|.|||||||...:|.||||::||||||:||:|      |:|:.|
  Fly   400 VPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSG--- 461

Human   426 EQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVH 490
            |.|.|||||||||||..|...|::||.|||.||||.||||||||||.|.|..|.:..|..||:.|
  Fly   462 ESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKH 526

Human   491 LRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGG 555
            |..:||:|  .....:::||.|||||||||:|||||||||.|||:....::.|:.|.|:||::||
  Fly   527 LSSVKLES--PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGG 589

Human   556 LEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPR-GKGLGYAQYLPKEQYLYTKE 619
            .||::..|...|:|.:||||:|||:.||.|.::|.||||:|:|| ...||:|||.|.||:||:||
  Fly   590 TEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKE 654

Human   620 QLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMV 684
            :|.|:|||.||||.:|.:.|.|||||||:||.|||:.||:||.:||||:.:|.|   ..|..|..
  Fly   655 ELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPI---YVRDADET 716

Human   685 L---------EKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKND 740
            .         :||:|.|...:||:|.|.::..||:.|..:||..:..:||:|..|||||.||.:.
  Fly   717 EGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQ 781

Human   741 MVELLGPRPF-AEKSTYE--EFVEGTGSLDEDT 770
            :|:|:||.|: ..|...|  ||.:...:|..||
  Fly   782 VVQLIGPPPYDLGKRQVESVEFEQSLKNLSTDT 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126		12/56 (21%)
		HflB	151..747	CDD:440233	290/630 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797		4/12 (33%)
Spg7	NP_570017.1	HflB	178..788	CDD:440233	290/626 (46%)