DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AFG3L2 and spg-7

DIOPT Version :9

Sequence 1:	NP_006787.2	Gene:	AFG3L2 / 10939	HGNCID:	315	Length:	797	Species:	Homo sapiens
Sequence 2:	NP_491165.2	Gene:	spg-7 / 171915	WormBaseID:	WBGene00004978	Length:	782	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	458/754 - (60%)
Similarity:	580/754 - (76%)	Gaps:	43/754 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    58 IIAAYQRFCSR---PPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRG 119
            ::|..|||..|   ..:...:||.:..|..|....||...:.|||..::..:.|         :|
Worm    52 LLAKDQRFEERFFNQVQQTIRYFASKPNDLKKFFRKEASTDNKESSSSSDKKDS---------KG 107

Human   120 GKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGV 184
            .|.:|::.:::|..|   |......:..| .||:  ..|.|    :|.|||:||:|.:::|..|:
Worm   108 NKGEDNNPFNQFPGG---WQQIAVSVGIL-LALY--AFMDY----QSYREISWKEFYSDFLEAGL 162

Human   185 VDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAES 249
            |:|||||:||:||:..:.||  ..||..:|||||||:|||:|...|..|..:.:.::||:|  :|
Worm   163 VERLEVVDKRWVRIVSSSGK--YAGQTCYFNIGSVDSFERSLGAAQHHLQYDADRQIPVLY--KS 223

Human   250 DGSFLLSMLPTVLIIAF------LLYTIRRGPAGIGRTGR----GMGGLF-SVGETTAKVL-KDE 302
            :.:|... :|.::.:||      .:|.:.:|....|..||    |:||:| ..|::||:|: :::
Worm   224 EFNFKRE-IPNLISVAFPLLFGYYIYRMLKGGGAAGGAGRAGGGGLGGMFGGFGQSTARVINRED 287

Human   303 IDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV 367
            |.|||.|||||||||:||||||||||||:||:|||||||||||||||||||||||||||||||||
Worm   288 IKVKFADVAGCEEAKIEIMEFVNFLKNPQQYKDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV 352

Human   368 PFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKR-GRGNFGGQSEQENTL 431
            ||||||||||||||||||||||||:|::||||:|||||||||||||||| |:|..||.|||||||
Worm   353 PFITVSGSEFLEMFVGVGPARVRDMFSMARKNSPCILFIDEIDAVGRKRGGKGGMGGHSEQENTL 417

Human   432 NQLLVEMDGFNT-TTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLK 495
            ||||||||||.| .::|:::|.|||.||||.||||||||||||::..||||||||||:|||.||:
Worm   418 NQLLVEMDGFTTDESSVIVIAATNRVDILDSALLRPGRFDRQIYVPVPDIKGRASIFRVHLGPLR 482

Human   496 LDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKT 560
              ::|:|..|:||||:.||||||||::||||||||||||..:..|:.||||||||||:.|:||||
Worm   483 --TSLDKTVLSRKLAAHTPGFSGADISNVCNEAALIAARDANHEISNKHFEQAIERVVAGMEKKT 545

Human   561 QVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRM 625
            ||||.||||||||||||||:|||:|:||||||||||||||||||||||||||||||:|:||||||
Worm   546 QVLQKEEKKTVAYHEAGHAIAGWFLQHADPLLKVSIIPRGKGLGYAQYLPKEQYLYSKDQLLDRM 610

Human   626 CMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYS 690
            ||||||||:||||||||||||||||:||||.||:|:|:|||:||||.:||:.|..|:|..:||||
Worm   611 CMTLGGRVAEEIFFGRITTGAQDDLQKVTQMAYSQVVKFGMSEKVGPLSFETPAPGEMAFDKPYS 675

Human   691 EATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKST 755
            ||||:|||.|||.|:.:|.:||..||.||::|:|:|||.|||||:|::.||:||:|.|||.||:|
Worm   676 EATAQLIDQEVRDLVMNALRRTRDLLLEKRSDIERVALRLLEKEILNREDMIELVGKRPFVEKNT 740

Human   756 YEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEK 794
            |||.|.|||.|||:..||:||::||||.||:|::...:|
Worm   741 YEEMVSGTGGLDENVELPKGLENWNKESEKKKKDEEKKK 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..126		13/49 (27%)
		FtsH_ext	146..242	CDD:310823	41/95 (43%)
		TIP49	253..746	CDD:332389	363/506 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..797		19/36 (53%)
spg-7	NP_491165.2	FtsH_ext	123..218	CDD:310823	42/103 (41%)
spg-7	NP_491165.2	TIP49	278..731	CDD:332389	349/454 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I938
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4947
Inparanoid	1	1.050	855	1.000	Inparanoid score	I224
Isobase	1	0.950	-	0	Normalized mean entropy	S505
OMA	1	1.010	-	-		QHG57866
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		oto21987
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2012
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820