Protein Alignment AFG3L2 and spg-7

DIOPT Version :10

• Sequence 1: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_491165.2
• Gene: spg-7 / 171915
• WormBaseID: WBGene00004978
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 754
• Identity: 458/754 - (60%)
• Similarity: 580/754 - (76%)
• Gaps: 43/754 - (5%)

Human    58 IIAAYQRFCSR---PPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRG 119
            ::|..|||..|   ..:...:||.:..|..|....||...:.|||..::..:.|         :|
 Worm    52 LLAKDQRFEERFFNQVQQTIRYFASKPNDLKKFFRKEASTDNKESSSSSDKKDS---------KG 107

Human   120 GKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGV 184
            .|.:|::.:::|..|   |......:..| .||:  ..|.|    :|.|||:||:|.:::|..|:
 Worm   108 NKGEDNNPFNQFPGG---WQQIAVSVGIL-LALY--AFMDY----QSYREISWKEFYSDFLEAGL 162

Human   185 VDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAES 249
            |:|||||:||:||:..:.||  ..||..:|||||||:|||:|...|..|..:.:.::||:|  :|
 Worm   163 VERLEVVDKRWVRIVSSSGK--YAGQTCYFNIGSVDSFERSLGAAQHHLQYDADRQIPVLY--KS 223

Human   250 DGSFLLSMLPTVLIIAF------LLYTIRRGPAGIGRTGR----GMGGLF-SVGETTAKVL-KDE 302
            :.:|... :|.::.:||      .:|.:.:|....|..||    |:||:| ..|::||:|: :::
 Worm   224 EFNFKRE-IPNLISVAFPLLFGYYIYRMLKGGGAAGGAGRAGGGGLGGMFGGFGQSTARVINRED 287

Human   303 IDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV 367
            |.|||.|||||||||:||||||||||||:||:|||||||||||||||||||||||||||||||||
 Worm   288 IKVKFADVAGCEEAKIEIMEFVNFLKNPQQYKDLGAKIPKGAILTGPPGTGKTLLAKATAGEANV 352

Human   368 PFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKR-GRGNFGGQSEQENTL 431
            ||||||||||||||||||||||||:|::||||:|||||||||||||||| |:|..||.|||||||
 Worm   353 PFITVSGSEFLEMFVGVGPARVRDMFSMARKNSPCILFIDEIDAVGRKRGGKGGMGGHSEQENTL 417

Human   432 NQLLVEMDGFNT-TTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLK 495
            ||||||||||.| .::|:::|.|||.||||.||||||||||||::..||||||||||:|||.||:
 Worm   418 NQLLVEMDGFTTDESSVIVIAATNRVDILDSALLRPGRFDRQIYVPVPDIKGRASIFRVHLGPLR 482

Human   496 LDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKT 560
              ::|:|..|:||||:.||||||||::||||||||||||..:..|:.||||||||||:.|:||||
 Worm   483 --TSLDKTVLSRKLAAHTPGFSGADISNVCNEAALIAARDANHEISNKHFEQAIERVVAGMEKKT 545

Human   561 QVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRM 625
            ||||.||||||||||||||:|||:|:||||||||||||||||||||||||||||||:|:||||||
 Worm   546 QVLQKEEKKTVAYHEAGHAIAGWFLQHADPLLKVSIIPRGKGLGYAQYLPKEQYLYSKDQLLDRM 610

Human   626 CMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYS 690
            ||||||||:||||||||||||||||:||||.||:|:|:|||:||||.:||:.|..|:|..:||||
 Worm   611 CMTLGGRVAEEIFFGRITTGAQDDLQKVTQMAYSQVVKFGMSEKVGPLSFETPAPGEMAFDKPYS 675

Human   691 EATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKST 755
            ||||:|||.|||.|:.:|.:||..||.||::|:|:|||.|||||:|::.||:||:|.|||.||:|
 Worm   676 EATAQLIDQEVRDLVMNALRRTRDLLLEKRSDIERVALRLLEKEILNREDMIELVGKRPFVEKNT 740

Human   756 YEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEK 794
            |||.|.|||.|||:..||:||::||||.||:|::...:|
 Worm   741 YEEMVSGTGGLDENVELPKGLENWNKESEKKKKDEEKKK 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126		13/49 (27%)
		HflB	151..747	CDD:440233	407/609 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797		19/36 (53%)
spg-7	NP_491165.2	HflB	126..732	CDD:440233	408/619 (66%)