Protein Alignment EHD1 and Past1

DIOPT Version :10

• Sequence 1: NP_001269374.1
• Gene: EHD1 / 10938
• HGNCID: 3242
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_731737.1
• Gene: Past1 / 41569
• FlyBaseID: FBgn0016693
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 368/540 - (68%)
• Similarity: 440/540 - (81%)
• Gaps: 9/540 - (1%)

Human    10 PVSGSMFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM 74
            |.:|..|.     .|.|...|:.:.|...|:::|..|||||||||:||:||||.|||.|||.|||
  Fly     4 PEAGDSFL-----KREKNTQEVVENVIGELKKIYRSKLLPLEEHYQFHDFHSPKLEDPDFDAKPM 63

Human    75 VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKL 139
            :|||||||||||||||:|:|:||||:|||||||||.|||||:...|||:|||||||||::.||.|
  Fly    64 ILLVGQYSTGKTTFIRYLLERDFPGIRIGPEPTTDRFIAVMYDDKEGVIPGNALVVDPKKQFRPL 128

Human   140 NAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFD 204
            :.:||||||||.|:.:.:|||::|||:|||||||||||||.|||||..|||||||||||||||||
  Fly   129 SKYGNAFLNRFQCSSVASPVLNAISIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFD 193

Human   205 AHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIG 269
            ||||||||||...|:|||.|:||||::|||||.|:.||||||||||||||||::.||||.|||||
  Fly   194 AHKLDISDEFRRSIEALKGHDDKIRIILNKADMIDHQQLMRVYGALMWSLGKVLQTPEVARVYIG 258

Human   270 SFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPN 334
            |||..||....||:|||.||||||:|:||||||||||||||||||||||||||:||:.|:|:||:
  Fly   259 SFWDQPLRFDANRRLFEDEEQDLFRDLQSLPRNAALRKLNDLIKRARLAKVHAFIIAELRKDMPS 323

Human   335 VFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDM 399
            ||||:||||:|:.|||::|.:|:|||.|||||||.::||||:||.|||:||.:|||.|||.||:|
  Fly   324 VFGKDSKKKDLIKNLGQVYDRIQREHSISPGDFPDIKKMQEVLQHQDFTKFHSLKPHLLDIVDNM 388

Human   400 LANDIARLMVMVRQEE-SLMPSQVVKGGAFDGTMN---GPFGHGYGEGAGEGIDDVEWVVGKDKP 460
            ||.||||||.|:.||| :::...:||||||:|.::   .|||:..|||...|..:.||:..||||
  Fly   389 LAKDIARLMEMIPQEEMTMVADPIVKGGAFEGVIDDHVSPFGYMKGEGIDAGYGEHEWICNKDKP 453

Human   461 TYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVK 525
            ..|.||..|.||:|||:||.||:|::||||||:||.|||||:|||.||.||.:|||||.|||.||
  Fly   454 RTDGIFNGLGPVDGKISGATAKQELIKSKLPNSVLSKIWKLSDVDGDGFLDSDEFALALHLINVK 518

Human   526 LEGHELPADLPPHLVPPSKR 545
            |||.|||..||.||||||||
  Fly   519 LEGCELPTVLPEHLVPPSKR 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHD1	NP_001269374.1	EHD_N	38..70	CDD:465295	21/31 (68%)
		EHD	74..314	CDD:206740	184/239 (77%)
		DUF5600	302..408	CDD:465667	77/105 (73%)
		EH	452..545	CDD:197477	64/92 (70%)
Past1	NP_731737.1	EHD_N	27..59	CDD:465295	21/31 (68%)
		EHD	63..303	CDD:206740	184/239 (77%)
		DUF5600	291..397	CDD:465667	77/105 (73%)
		EH	446..538	CDD:197477	63/91 (69%)