Protein Alignment MORF4L1 and msl-3

DIOPT Version :10

• Sequence 1: NP_996670.1
• Gene: MORF4L1 / 10933
• HGNCID: 16989
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_523951.1
• Gene: msl-3 / 38779
• FlyBaseID: FBgn0002775
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 106/539 - (19%)
• Similarity: 168/539 - (31%)
• Gaps: 240/539 - (44%)

Human     1 MAPKQDPKPKFQEGERVLCFH-----GPLLYEAKCVKVAIKDKQ-----VKYFIHYSGWNKKSAV 55
            |...:|..|.|.:||.|||:.     ..:||.:|.:.|..:..:     .:|.||:.||
  Fly     1 MTELRDETPLFHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGW------ 59

Human    56 RPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQ 120
            ||                                 |:|..|..:.:||..:.|.|.||||.:|
  Fly    60 RP---------------------------------SYDRCVRATVLLKDTEENRQLQRELAEA-- 89

Human   121 EQYAEGKMRG-----AAP----GKKTSGLQQKNVE-----------VKTKKNKQKTP---GN--- 159
               |:.::||     ..|    .||..|.:..:||           ::.:.....||   ||
  Fly    90 ---AKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRTR 151

Human   160 -GDGGSTSETPQPP----RKKRARVDPTVENEETFMNRV--------------EVKVKIPEELKP 205
             ..||...|  :||    |.|..|...|    |||.|..              .:.:::.|.|:.
  Fly   152 DNSGGKRKE--KPPSGDGRLKGNRGRQT----ETFYNNAINDVSVYNHVPQEDRIMMRVSERLRE 210

Human   206 WLVDDWDLITRQKQLFYLPAKKNVDSILEDY------------------ANYKKSRGNTDNKEY- 251
            .:..|.::|....:...|||:..:.:|:|::                  |...:||.....:||
  Fly   211 LIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQSRNARMEREYD 275

Human   252 -------AVNEVVAGIKEYFNVMLGTQLLYKFER------------------------------- 278
                   .:.|||.|::.||...:...|||..|:
  Fly   276 RVMSTVCMLKEVVDGLRIYFEFHVDDHLLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGD 340

Human   279 -----------------------------PQYAE------------------------------- 283
                                         |:|.:
  Fly   341 TELIGLDGTPVVEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAY 405

Human   284 -----------------ILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLH 331
                             :|:.......|.|:|||||:||.:::...|..:|:..|.|..||.:|.
  Fly   406 KLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLD 470

Human   332 DFLKYLAKNSATLFSASDY 350
            .|:.|| :|....|...::
  Fly   471 AFINYL-ENHREWFDRENF 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MORF4L1	NP_996670.1	CBD_MSL3_like	15..110	CDD:350846	21/104 (20%)
		Interaction with KAT8. /evidence=ECO:0000269|PubMed:12397079	26..62		10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..182		25/99 (25%)
		Sufficient for interaction with SIN3A. /evidence=ECO:0000269|PubMed:12391155	133..266		43/198 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	135..146		3/10 (30%)
		Interaction with RB1-1	164..230		18/83 (22%)
		MRG	176..351	CDD:461721	54/323 (17%)
		Sufficient for interaction with PHF12. /evidence=ECO:0000269|PubMed:12391155	188..342		50/301 (17%)
		Interaction with RB1-2	323..344		8/20 (40%)
msl-3	NP_523951.1	CD_CSD	15..81	CDD:475127	21/104 (20%)
		MRG	196..490	CDD:461721	48/294 (16%)